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Peters-Engl, C; Medl, M; Denison, U; Sevelda, P; Leodolter, S; Petru, E.
Does long-term application of granulocyte colony-stimulating factor adversely influence overall survival in patients with ovarian cancer? A clinical study.
ANTICANCER RES. 2002; 21(5): 3701-3706.
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Co-authors Med Uni Graz: Petru Edgar
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Abstract:: The purpose of this study was to investigate the effect of long-term administration of G-CSF with regard to its impact on overall survival of patients with ovarian cancer. We report the results of a non-randomized trial on 64 patients with advanced ovarian cancer treated with 6 cycles of conventional chemotherapy. Chemotherapy comprised carboplatin 400 mg/m2 and epirubicin 70 mg/m2 on day 1 of each cycle and prednimustine 100 mg/m2 on days 3 to 7, every 28 days. Thirty-three patients received CEP chemotherapy with G-CSF support whereas 31 women received CEP chemotherapy alone. The schedule of G-CSF was 5 mg/kg/day subcutanously on days 8 to 21 of each cycle. The severity of reduction in white cells and neutrophil count was significantly different in the two treatment groups (p<0.05), with more toxicity in the non- G-CSF group. G-CSF users had a non significant 0.88-fold lower risk of dying from ovarian cancer (95% CI, 0.48-1.60, p=0.678). In a survival analysis using a Cox proportional hazards model, residual tumor remained as an independent prognostic factor. The increasing amount of residual tumor resulted in a 1.767-fold higher risk (95% CI, 1.23-2.53, p=0.002) of death secondary to the underlying disease. In conclusion, this trial has failed to demonstrate any negative impact on patients' overall survival for the additional use of G-CSF with platinum-based chemotherapy; our results were consistent with the beneficial effects of G-CSF treatment on cytotoxic chemotherapy-induced myelosuppression.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Aged -; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Carboplatin - administration and dosage; Drug Administration Schedule - administration and dosage; Epirubicin - administration and dosage; Female - administration and dosage; Granulocyte Colony-Stimulating Factor - administration and dosage; Humans - administration and dosage; Middle Aged - administration and dosage; Ovarian Neoplasms - drug therapy; Prednimustine - administration and dosage; Survival Rate - administration and dosage
Find related publications in this database (Keywords): G-CSF; ovarian neoplasm; survival