Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Riccabona, M; Kerbl, R; Schwinger, W; Spork, D; Millner, M; Grubbauer, HM.
Ceftriaxone-induced cholelithiasis--a harmless side-effect?
KLIN PADIAT. 1993; 205(6): 421-423.
Doi: 10.1055/s-2007-1025261
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Riccabona Michael
- Co-Autor*innen der Med Uni Graz
- Grubbauer Hans
- Kerbl Reinhold
- Schwinger Wolfgang
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- Abstract:
- 43 children suffering from borreliosis, meningitis and septicemia were treated with ceftriaxone. A six year old boy with acute jaundice due to ceftriaxone induced cholelithiasis encouraged us to reevaluate the frequency of ceftriaxone induced cholelithiasis and its' sequelae in children in a prospective study. Out of 43 children (age 6.3 years, 4 months to 16 years, male: female 25:18), 20 children (46.5%) showed sonographical evidence for ceftriaxone induced cholelithiasis after a treatment of at least 10 days. Two of them even had signs of intrahepatic cholestasis, 3 kids suffered from severe abdominal pain, non of them showed serologic abnormalities. Another 5 children (11.6%) had sludge in the gallbladder without evidence for cholelithiasis. In all patients the "pseudocholelithiasis" spontaneously resolved within at most 2 months. We suggest a sonographical examination of the gallbladder at the end of the ceftriaxone treatment in order to detect cholelithiasis, which might call for further monitoring and maybe dietary treatment.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Ceftriaxone - adverse effects
- Child - adverse effects
- Child, Preschool - adverse effects
- Cholelithiasis - chemically induced
- Encephalitis - drug therapy
- Female - drug therapy
- Follow-Up Studies - drug therapy
- Humans - drug therapy
- Infant - drug therapy
- Lyme Disease - drug therapy
- Male - drug therapy
- Meningitis, Bacterial - drug therapy
- Sepsis - drug therapy