Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Malle, E; Wäg, G; Thiery, J; Sattler, W; Gröne, HJ.
Hypochlorite-modified (lipo)proteins are present in rabbit lesions in response to dietary cholesterol.
Biochem Biophys Res Commun. 2001; 289(4):894-900
Doi: 10.1006/bbrc.2001.6074
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Malle Ernst
- Co-Autor*innen der Med Uni Graz
- Sattler Wolfgang
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- Abstract:
- Myeloperoxidase (MPO), a heme enzyme secreted by activated phagocytes, generates an array of oxidants proposed to play critical roles in host defense, tissues damage, and foam cell formation. Although neutrophils are the major source for MPO, the enzyme could be identified abundantly in circulating monocytes and monocytes/macrophages in rabbit lesions. MPO is the only enzyme known to generate hypochlorous acid (HOCl) and HOCl-modified lipoproteins have pronounced atherogenic and/or proinflammatory features in vivo and in vitro. Using specific monoclonal antibodies, HOCl-modified (lipo)proteins were detected in atherosclerotic plaques of heterozygous Watanabe heritable hyperlipidemic rabbits and to a lesser extent in a specific strain of New Zealand White rabbits with a high atherosclerotic response to hypercholesterolemia. Colocalization of immunoreactive MPO and HOCl-modified-epitopes in serial sections of rabbit lesions provides convincing evidence for MPO-H2O2-chloride system-mediated oxidation of (lipo)proteins under in vivo conditions. We propose that monocyte-derived MPO could connect chronic inflammatory conditions with arterial lipid/lipoprotein deposition during diet-induced atherogenesis in rabbits.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Arteriosclerosis - etiology
- Cholesterol, Dietary - administration and dosage
- Diet, Atherogenic - administration and dosage
- Disease Models, Animal - administration and dosage
- Humans - administration and dosage
- Hyperlipidemias - genetics
- Hypochlorous Acid - metabolism
- Inflammation - metabolism
- Lipoproteins - chemistry
- Monocytes - metabolism
- Oxidants - metabolism
- Peroxidase - metabolism
- Proteins - chemistry
- Rabbits - chemistry
- Find related publications in this database (Keywords)
- myeloperoxidase
- oxidized lipoproteins
- modified lipoproteins
- atherogenesis
- inflammation
- hypochlorous acid