Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Schaffler, GJ; Kugler, CH; Schreyer, G; Graber, G; Uggowitzer, MM.
Quantitative and qualitative analysis of in vivo Doppler signal enhancement of FS-069.
Invest Radiol. 2002; 37(1):1-6
Doi: 10.1097%2F00004424-200201000-00002
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- Führende Autor*innen der Med Uni Graz
- Schaffler Gottfried
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- Abstract:
- RATIONALE AND OBJECTIVES: In vivo lifetime of ultrasound (US) contrast agents is still limited and thus a cause for ongoing investigations of new substances. The purpose of this study was to determine the time intensity changes of the Doppler signals obtained within the femoral vein after two different doses of a new microsphere-based ultrasound contrast agent. METHODS: Twenty-four healthy male volunteers (mean age, 29; average weight, 76 kg) were included in this study. All underwent a triplex Doppler US examination after an intravenous bolus injection of 0.3 mL and 1.0 mL Optison. To examine the signal enhancement characteristics of this contrast agent the audio signal of the pulsed-wave spectral Doppler US was measured quantitatively using an audio analyzer, whereas velocity-encoded color Doppler examinations were scored qualitatively (score 0-3). RESULTS: The mean maximal enhancement of the audio signal at a dose of 1.0 mL FS-069 was significantly higher than with a bolus of 0.3 mL FS-069 (29 +/- 2 dB vs. 26 dB +/- 2 dB, P < 0.001). The time-intensity curves after each bolus injection yielded an early peak (one minute after the injection) followed by constantly decreasing signal intensities. The scoring of the velocity-encoded color Doppler US revealed an optimal enhancement (score 2) for 3 minutes and 20 seconds (0.3 mL Optison) and for 6 minutes (1.0 mL Optison), respectively. CONCLUSIONS: This study showed the capability of triplex Doppler ultrasound signal enhancement after Optison. 1.0 mL Optison proved to be the more appropriate dose for an optimal signal enhancement than 0.3 mL Optison.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Albumins - diagnostic use
- Contrast Media - diagnostic use
- Femoral Vein - ultrasonography
- Fluorocarbons - diagnostic use
- Humans - diagnostic use
- Male - diagnostic use
- Microspheres - diagnostic use
- Middle Aged - diagnostic use
- Prospective Studies - diagnostic use
- Ultrasonography, Doppler - methods
- Find related publications in this database (Keywords)
- ultrasound
- Doppler signal enhancement
- Optison
- time intensity curve
- femoral vein