Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Hauner, H; Petzinna, D; Sommerauer, B; Toplak, H.
Effect of acarbose on weight maintenance after dietary weight loss in obese subjects.
Diabetes Obes Metab. 2001; 3(6):423-427
Doi: 10.1046%2Fj.1463-1326.2001.00156.x
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Toplak Hermann
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- Abstract:
- AIMS: Acarbose is a well established antidiabetic drug and is known to exert a modest weight-lowering effect. The aim of this study was to assess the potential of acarbose to improve weight maintenance after a substantial weight loss by dietary measures in obese subjects. DESIGN: Randomised, double-blind, placebo-controlled trial of the effect of acarbose on weight change over a 6-month follow-up period. PATIENTS AND METHODS: One hundred and ten obese subjects with a BMI > or = 32 and < or = 38 kg/m2 were included in the study and underwent a 10-16-week very-low-calorie diet programme to initiate weight loss. Then, subjects were randomised to receive either acarbose or placebo for 26 +/- 2 weeks. The primary variable was body weight. The primary efficacy analysis was performed in the per-protocol population (n = 75). RESULTS: After an initial mean weight loss of 10.0 +/- 3.4 kg, 54 subjects received acarbose at increasing dosage and 56 subjects received placebo treatment. After 14 weeks of follow-up, there was no change in body weight in the two groups. After 26 weeks, completed by 37 subjects in the acarbose group and by 38 subjects in the placebo group, a small weight regain of 0.6 kg was documented in the latter, whereas no weight increase was observed under acarbose treatment (p = 0.38, analysis of covariance with initial body weight as covariable). CONCLUSION: In obese individuals who undergo a hypocaloric diet and achieve a substantial loss of body weight, acarbose treatment provides only a very modest, not significant benefit to stabilise weight reduction. Thus, acarbose is not a useful adjunct to improve weight maintenance in obese subjects after weight loss.
- Find related publications in this database (using NLM MeSH Indexing)
- Acarbose - therapeutic use
- Adult - therapeutic use
- Blood Glucose - metabolism
- Body Mass Index - metabolism
- Body Weight - drug effects
- Double-Blind Method - drug effects
- Female - drug effects
- Hemoglobin A, Glycosylated - metabolism
- Humans - metabolism
- Hypoglycemic Agents - therapeutic use
- Male - therapeutic use
- Middle Aged - therapeutic use
- Obesity - drug therapy
- Placebos - drug therapy
- Time Factors - drug therapy
- Weight Loss - drug effects
- Find related publications in this database (Keywords)
- acarbose
- weight maintenance
- obesity
- weight loss