Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Michl, T; Jocic, M; Schuligoi, R; Holzer, P.
Role of tachykinin receptors in the central processing of afferent input from the acid-threatened rat stomach.
REGUL PEPTIDES 2001 102: 119-126.
Doi: 10.1016%2FS0167-0115%2801%2900309-3
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- Führende Autor*innen der Med Uni Graz
- Holzer Peter
- Co-Autor*innen der Med Uni Graz
- Schuligoi Rufina
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- Abstract:
- Noxious challenge of the rat gastric mucosa by hydrochloric acid (HCl) is signalled via vagal afferent neurons to several brain nuclei in which tachykinins and tachykinin receptors are present. Therefore, we tested whether tachykinin receptor antagonists would modify the central transmission of input from the acid-threatened stomach. Neuronal excitation was visualized by in situ hybridization autoradiography (ISH) of c-fos messenger ribonucleic acid (mRNA) 45 min after intragastric (IG) administration of HCl (0.5 M; 10 ml/kg). This stimulus has previously been shown to cause neurons in the nucleus tractus solitarii (NTS), lateral parabrachial nucleus (LPB), paraventricular (Pa) nuclei, supraoptic (SO) nucleus, central amygdala (CeA), area postrema (AP), subfornical organ (SFO) and habenula (Hb) to express c-fos mRNA. Intraperitoneal (IP) pretreatment with the NK1 receptor antagonist GR-205,171 (3 mg/kg) attenuated the acid-induced transcription of c-fos mRNA in NTS and augmented it in SFO. The NK2 receptor antagonist SR-144,190 (0.1 mg/kg, IP) had no effect. Subcutaneous administration of the NK3 receptor antagonist SB-222,200 (20 mg/kg) reduced the c-fos mRNA response in AP and SFO and enhanced it in Hb. These data show that the transmission of input from the acid-threatened stomach in distinct brain nuclei involves tachykinins acting at NK1 and NK3 receptors, but not NK2 receptors.
- Find related publications in this database (using NLM MeSH Indexing)
- Afferent Pathways - drug effects
- Animals - drug effects
- Antiemetics - pharmacology
- Autoradiography - pharmacology
- Brain - metabolism
- Female - metabolism
- Gastric Mucosa - drug effects
- Gene Expression - drug effects
- Hydrochloric Acid - pharmacology
- In Situ Hybridization - pharmacology
- Methylurea Compounds - pharmacology
- Morpholines - pharmacology
- Piperidines - pharmacology
- Proto-Oncogene Proteins c-fos - genetics
- Quinolines - pharmacology
- RNA, Messenger - genetics
- Rats - genetics
- Rats, Sprague-Dawley - genetics
- Receptors, Tachykinin - antagonists and inhibitors
- Research Support, Non-U.S. Gov't - antagonists and inhibitors
- Stomach - drug effects
- Tetrazoles - pharmacology
- Find related publications in this database (Keywords)
- expression of c-fos mRNA in rat brain
- gastric mucosal acid insult
- tachykinin NK1
- NK2
- and NK3 receptors
- tachykinin receptor antagonists
- visceral nociception