Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Stanger, O; Renner, W; Khoschsorur, G; Rigler, B; Wascher, TC.
NADH/NADPH oxidase p22 phox C242T polymorphism and lipid peroxidation in coronary artery disease.
Clin Physiol. 2001; 21(6):718-722
Doi: 10.1046%2Fj.1365-2281.2001.00381.x
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Co-Autor*innen der Med Uni Graz
- Khoschsorur Gholamali
- Renner Wilfried
- Rigler Bruno
- Wascher Thomas
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The nicotinamide adenine dinucleotide (NADH)/nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system is a major source of superoxide anion (.O2-) production in the human vasculature and may therefore influence lipid peroxidation and severity of atherosclerosis. This study aimed to investigate a hypothetical influence of the p22 phox C242T polymorphism on the generation of malondialdehyde (MDA), extent and clinical onset of coronary artery disease (CAD) in patients. We studied 108 male Caucasians with angiographically documented CAD and 45 controls free of vascular disease under 60 years of age. p22 phox C242T genotypes and MDA levels were determined. Additional information was obtained from each subject on classic risk factors and clinical events of CAD. Genotype distribution in CAD-patients and controls was thymine-thymine (TT): 13.8% (13.3%), cytosine-thymine (CT): 46.3% (53.3%) and cytosine-cytosine (CC): 39.8% (33.3%), respectively. No significant influence was seen of the p22 phox C242T polymorphism on corresponding mean MDA levels in both groups. Furthermore, age at onset of first time angina pectoris (AP) and myocardial infarction (MCI) was not significantly different between genotype groups. It is concluded that the C242T polymorphism of the p22 phox gene is not associated with lipid peroxidation as measured by MDA, and is not a genetic risk marker for CAD Caucasians.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Age of Onset -
- Angina Pectoris - physiopathology
- Angiography - physiopathology
- Coronary Arteriosclerosis - genetics
- Genotype - genetics
- Humans - genetics
- Lipid Peroxidation - physiology
- Male - physiology
- Malondialdehyde - analysis
- Membrane Transport Proteins - analysis
- Middle Aged - analysis
- Myocardial Infarction - physiopathology
- NAD - genetics
- NADH, NADPH Oxidoreductases - genetics
- NADPH Dehydrogenase - genetics
- NADPH Oxidase - genetics
- Phosphoproteins - genetics
- Polymorphism, Genetic - genetics
- Polymorphism, Restriction Fragment Length - genetics
- Risk Factors - genetics
- Find related publications in this database (Keywords)
- atherosclerosis
- coronary disease
- free radicals
- gene expression