Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Weger, M; Renner, W; Stanger, O; Schmut, O; Deutschmann, H; Wascher, TC; Haas, A.
Role of factor XIII Val34Leu polymorphism in retinal artery occlusion.
Stroke. 2001; 32(12):2759-2761
Doi: 10.1161/hs1201.99889
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- Führende Autor*innen der Med Uni Graz
- Weger Martin
- Co-Autor*innen der Med Uni Graz
- Deutschmann Hannes
- Haas Anton
- Renner Wilfried
- Schmut Otto
- Wascher Thomas
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- Abstract:
- BACKGROUND AND PURPOSE: Factor XIII (FXIII) Val34Leu, a common polymorphism in the gene for factor XIII, has been associated with a lower risk of stroke, myocardial infarction, and deep vein thrombosis. Ineffective fibrin cross-linking has been suggested to be causative. The aim of the present case-control study was to investigate the role of FXIII Val34Leu polymorphism in patients with retinal artery occlusion. METHODS: A total of 108 patients with retinal artery occlusion and 313 age- and sex-matched controls were genotyped for the FXIII Val34Leu polymorphism. Factor XIII Val34Leu genotypes were determined by use of allele-specific polymerase chain reaction. RESULTS: Homozygous Leu genotype was found significantly more often in control subjects than in patients with retinal artery occlusion (P=0.018), with an odds ratio of 0.22 (95% confidence interval 0.07 to 0.74). Distribution of the Val/Val and Val/Leu genotypes did not differ significantly between groups. CONCLUSIONS: Because prevalence of homozygous Leu genotype was significantly higher in controls, we conclude that the Leu/Leu genotype is associated with a protective effect against retinal artery occlusion.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Age Distribution -
- Aged -
- Aged, 80 and over -
- Alleles -
- Amino Acid Substitution - genetics
- Case-Control Studies - genetics
- Factor XIII - genetics
- Female - genetics
- Gene Frequency - genetics
- Genetic Screening - genetics
- Genotype - genetics
- Homozygote - genetics
- Humans - genetics
- Immunity, Natural - genetics
- Male - genetics
- Middle Aged - genetics
- Odds Ratio - genetics
- Polymerase Chain Reaction - genetics
- Polymorphism, Genetic - genetics
- Prevalence - genetics
- Retinal Artery Occlusion - epidemiology
- Retrospective Studies - epidemiology
- Risk Factors - epidemiology
- Sex Distribution - epidemiology
- Find related publications in this database (Keywords)
- coagulation
- factor XIII
- genetics
- retinal artery occlusion