Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Toplak, H; Sagmeister, E; Wascher, TC.
Cardiovascular risk factors in obesity. The effect of weight reduction on platelet size in overweight patients.
Int J Obes Relat Metab Disord. 1994; 18(5):355-356
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- Führende Autor*innen der Med Uni Graz
- Toplak Hermann
- Co-Autor*innen der Med Uni Graz
- Wascher Thomas
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- Abstract:
- Platelet volume, indicating platelet activity has been proposed as a further independent risk factor for cardiovascular disease (CVD). It is well established that weight reduction reduces some of the risk factors for CVD in obese patients. We therefore retrospectively investigated the effects of weight reduction on platelet mass, platelet volume and serum lipid profile in patients undergoing an eight-week weight reduction therapy. During weight reduction, the body mass index (P < 0.005), serum total cholesterol (P < 0.05), LDL cholesterol (P < 0.01) and serum triglycerides (P < 0.01) were significantly reduced, while HDL cholesterol remained unchanged. On the other hand, platelet mass (P < 0.005) and platelet volume (P < 0.0005) increased significantly within the same period. We therefore conclude that fasting might alter the control of platelet size with a possible impact on platelet activity. This might result in an increased risk of thrombo-embolic ischaemic events in atherosclerotic patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Blood Platelets - physiology
- Body Mass Index - physiology
- Cardiovascular Diseases - blood
- Cholesterol - blood
- Diet, Reducing - blood
- Female - blood
- Humans - blood
- Male - blood
- Middle Aged - blood
- Obesity - blood
- Platelet Count - blood
- Retrospective Studies - blood
- Risk Factors - blood
- Triglycerides - blood
- Weight Loss - physiology
- Find related publications in this database (Keywords)
- Weight Reduction
- Platelet Size
- Platelet Mass
- Cardiovascular Disease