Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Hartung, HP; Reiners, K; Archelos, JJ; Michels, M; Seeldrayers, P; Heidenreich, F; Pflughaupt, KW; Toyka, KV.
Circulating adhesion molecules and tumor necrosis factor receptor in multiple sclerosis: correlation with magnetic resonance imaging.
ANN NEUROL. 1995; 38(2): 186-193. Doi: 10.1002/ana.410380210
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Co-Autor*innen der Med Uni Graz: Archelos-Garcia Juan-Jose
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Abstract:: Adhesion molecules are important in T-cell trafficking to sites of inflammation. We determined levels of circulating vascular cell adhesion molecule-1 (VCAM-1), L-selectin, and E-selectin in the serum of 147 patients with definite multiple sclerosis of the remitting-relapsing or secondary progressive type. Soluble VCAM-1 and L-selectin concentrations were increased compared to levels in a large group of control subjects. Levels were highest in patients with gadolinium-enhancing lesions on magnetic resonance imaging (VCAM-1: 1,011 +/- 276 vs 626 +/- 87 ng/ml; L-selectin: 1,130 +/- 272 vs 793 +/- 207 ng/ml [mean +/- standard deviation]; p < 0.0001 vs patients without enhancing lesions). Serum levels of soluble tumor necrosis factor receptor (60 kd) were also raised (2.64 +/- 1.23 vs 2.17 +/- 0.69 ng/ml in subjects with other neurological diseases and 2.1 +/- 0.77 ng/ml in healthy control subjects; p < 0.05). Soluble VCAM-1 and L-selectin levels were correlated to concentrations of soluble tumor necrosis factor receptor. In 13 patients with viral encephalitis, similar observations were made. Raised levels of soluble VCAM-1 and L-selectin probably reflect cytokine-induced endothelial cell and T-lymphocyte/monocyte activation occurring in the process of T-cell migration into the central nervous system. Tumor necrosis factor-alpha may be critically involved.
Find related publications in this database (using NLM MeSH Indexing): Cell Adhesion Molecules - blood; E-Selectin - blood; Female - blood; Humans - blood; L-Selectin - blood; Magnetic Resonance Imaging - blood; Male - blood; Multiple Sclerosis - blood; Receptors, Tumor Necrosis Factor - analysis; Vascular Cell Adhesion Molecule-1 - analysis