Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Archelos, JJ; Jung, S; Rinner, W; Lassmann, H; Miyasaka, M; Hartung, HP.
Role of the leukocyte-adhesion molecule L-selectin in experimental autoimmune encephalomyelitis.
J Neurol Sci. 1998; 159(2):127-134
Doi: 10.1016/S0022-510X(98)00154-3
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- Führende Autor*innen der Med Uni Graz
- Archelos-Garcia Juan-Jose
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- Abstract:
- L-selectin is an adhesion molecule expressed on T cells and monocytes. It mediates rolling--the initial step of transendothelial migration. In this study, we investigated the role of L-selectin in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. EAE was induced in Lewis rats by active sensitization with myelin basic protein (MBP-EAE), or by adoptive transfer using MBP specific T cells (AT-EAE). Treatment with HRL3, a monoclonal antibody to L-selectin, and its F(ab')2 fragments efficiently suppressed MBP-EAE, and had a mild inhibitory effect on AT-EAE. Histological examination revealed a marked reduction of inflammatory infiltrates after treatment with HRL3. Administration of the control antibody HRL4 did not significantly alter the course of the disease. HRL3 caused T-cell depletion in the draining lymph nodes and spleen and a downregulation of L-selectin expression on T cells. We conclude that L-selectin-dependent mechanisms are involved in the pathogenesis of EAE. Modulation of L-selectin in vivo by antibodies or by competitive antagonists could be a novel therapeutic approach to autoimmune diseases of the central nervous system.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antibodies, Monoclonal -
- Antibody Specificity -
- Brain - pathology
- Cricetinae - pathology
- Encephalomyelitis, Autoimmune, Experimental - pathology
- Female - pathology
- L-Selectin - physiology
- Lymph Nodes - immunology
- Neuritis - pathology
- Rats - pathology
- Rats, Inbred Lew - pathology
- Spleen - immunology
- Find related publications in this database (Keywords)
- EAE
- autoimmune disease
- adhesion molecules
- CNS
- therapy