Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Benesch, M; Lackner, H; Moser, A; Kerbl, R; Schwinger, W; Oberbauer, R; Eder, HG; Mayer, R; Wiegele, K; Urban, C.
Outcome and long-term side effects after synchronous radiochemotherapy for childhood brain stem gliomas.
Pediatr Neurosurg. 2001; 35(4):173-180
Doi: 10.1159%2F000050418
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- Führende Autor*innen der Med Uni Graz
- Benesch Martin
- Urban Ernst-Christian
- Co-Autor*innen der Med Uni Graz
- Eder Hans
- Kerbl Reinhold
- Lackner Herwig
- Mayer Ramona
- Nebl Andrea Maria
- Schwinger Wolfgang
- Wiegele Karin
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- Abstract:
- Between 1993 and 1999, 11 children with histologically confirmed diffuse and exophytic brain stem glioma (BSG) were treated with intensive induction chemotherapy and simultaneous external beam irradiation. Chemotherapy was performed according to the German/Austrian Pediatric Brain Tumor Study HIT '91 and included two cycles of ifosfamide (days 1-3), etoposide (days 4-6), methotrexate (days 15 and 22), cisplatin (days 29-31) and cytarabine (days 29-31), separated by a 3-week interval. Maintenance chemotherapy with carmustine, carboplatin and vincristine (8 cycles over a 1-year period) was given in those patients who responded clinically or radiographically to induction chemotherapy. Six of 11 patients showed an objective reduction in tumor size on magnetic resonance imaging and 4 of 11 are alive in good general condition >22, >22, >90 and >92 months, respectively, after diagnosis without radiographic evidence of tumor progression (1 complete remission, 2 partial remissions, 1 stable disease), but suffer from moderate to severe long-term side effects. Three patients died due to disease progression after having achieved a partial remission which lasted 5, 6 and 18 months, respectively, whereas only short-term stabilization was observed in 4 patients who died within 1 year after diagnosis. Acute hematologic toxicity was severe but manageable. This intensive combined modality treatment was toxic but yielded objective responses in more than 50% and long-term survivors in one third of childhood BSG patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use
- Brain - drug effects Brain - pathology Brain - radiation effects
- Brain Stem Neoplasms - drug therapy Brain Stem Neoplasms - mortality Brain Stem Neoplasms - radiotherapy
- Child -
- Child, Preschool -
- Combined Modality Therapy -
- Cranial Irradiation - adverse effects
- Disease Progression -
- Female -
- Follow-Up Studies -
- Glioma - drug therapy Glioma - mortality Glioma - radiotherapy
- Humans -
- Magnetic Resonance Imaging -
- Male -
- Radiation Injuries - etiology Radiation Injuries - mortality
- Survival Rate -
- Find related publications in this database (Keywords)
- brain stem gliomas
- synchronous radiochemotherapy
- children
- treatment