Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Leithner, A; Lang, S; Windhager, R; Leithner, K; Karlic, H; Kotz, R; Haas, OA.
Expression of insulin-like growth factor-I (IGF-I) in aneurysmal bone cyst.
Mod Pathol. 2001; 14(11):1100-1104
Doi: 10.1038/modpathol.3880443
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- Führende Autor*innen der Med Uni Graz
- Leithner Andreas
- Windhager Reinhard
- Co-Autor*innen der Med Uni Graz
- Leithner Katharina
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- Abstract:
- The effects of insulin-like growth factor-I on bone tissue and its role in bone development have been extensively investigated, but there is little information on its role in the pathogenesis of aneurysmal bone cyst. Therefore, using the techniques of immunohistochemistry and in situ hybridization, the authors studied the expression of insulin-like growth factor-I in 19 specimens of aneurysmal bone cyst. Insulin-like growth factor-I or specific mRNA sequences encoding for insulin-like growth factor-I were detectable in all specimens tested and were mainly localized in multinucleate giant cells. In contrast, only insignificant levels of insulin-like growth factor-I expression were detectable in normal human bone tissue. Taken together with the previously reported role of insulin-like growth factor-I in the pathogenesis of giant cell tumor, the findings of this study suggest that insulin-like growth factor-I may play a role in the pathogenesis of aneurysmal bone cyst.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Bone Cysts, Aneurysmal - genetics
- Child - genetics
- Female - genetics
- Gene Expression - genetics
- Humans - genetics
- Immunohistochemistry - genetics
- In Situ Hybridization - genetics
- Insulin-Like Growth Factor I - analysis
- Male - analysis
- Middle Aged - analysis
- RNA, Messenger - genetics
- Find related publications in this database (Keywords)
- aneurysmal bone cyst
- giant cell tumor
- immunohistochemistry
- in situ hybridization
- insulin-like growth factor-I