Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Köppel, H; Gasser, R; Pokan, R; Willomitzer, R; Cichocki, L; Pilger, E; Klein, W.
Protection against myocardial ischemia by nisoldipine--an experimental study with valinomycin K-sensitive microelectrodes
Acta Med Austriaca. 1998; 25(3):101-105
Web of Science
PubMed
- Führende Autor*innen der Med Uni Graz
- Gasser Robert
- Köppel Herwig
- Co-Autor*innen der Med Uni Graz
- Pilger Ernst
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- Abstract:
- It has been shown that dihydropyridines exert a cardioprotective effect during experimental ischemia. This effect is reflected in a reduced K-efflux from the ischemic tissue. Recently we have shown that ischemic K-efflux is largely mediated by ATP-dependent K-channels. Using K-selective microelectrodes we studied the effect of nisoldipine on K-efflux during simulated ischemia (guinea pig papillary muscle immersed in paraffin oil; normal Tyrode solution, HEPES buffered, 100% O2-equilibrated, 37 degrees C). While ischemic K-efflux was Ca-dependent in stimulated preparations, it was independent of extracellular Ca in resting preparations. Our results show that nisoldipine leads to an inhibition of ischemic K-efflux during simulated ischemia. In resting preparations this inhibition is not a direct Ca-antagonistic effect, since withdrawal of extracellular Ca does not inhibit ischemic K-efflux but nisoldipine does. We suggest a direct effect of nisoldipine on the KATP channel which is mainly responsible for ischemic K-loss.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Calcium Channel Blockers - pharmacology
- Culture Techniques - pharmacology
- Electrocardiography - instrumentation
- Guinea Pigs - instrumentation
- Microelectrodes - instrumentation
- Myocardial Ischemia - physiopathology
- Nisoldipine - pharmacology
- Papillary Muscles - drug effects
- Potassium - metabolism
- Potassium Channels - drug effects
- Valinomycin - drug effects
- Find related publications in this database (Keywords)
- Nisoldipine
- Heart
- Myocardium
- Ischemia