Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Kersten, JR; Toller, WG; Tessmer, JP; Pagel, PS; Warltier, DC.
Hyperglycemia reduces coronary collateral blood flow through a nitric oxide-mediated mechanism.
AMER J PHYSIOL-HEART CIRC PHY 2001 281: H2097-H2104.
Doi: 10.1152/ajpheart.2001.281.5.H2097
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- Co-Autor*innen der Med Uni Graz
- Toller Wolfgang
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- Abstract:
- We tested the hypothesis that hyperglycemia alters retrograde coronary collateral blood flow by a nitric oxide-mediated mechanism in a canine Ameriod constrictor model of enhanced collateral development. Administration of 15% dextrose to increase blood glucose concentration to 400 or 600 mg/dl decreased retrograde blood flow through the left anterior descending coronary artery to 78 +/- 9 and 82 +/- 8% of baseline values, respectively. In contrast, saline or L-arginine (400 mg x kg(-1) x h(-1)) had no effect on retrograde flow. Coronary hypoperfusion and 1 h of reperfusion decreased retrograde blood flow similarly in saline- or L-arginine-treated dogs (76 +/- 11 and 89 +/- 4% of baseline, respectively), but these decreases were more pronounced in hyperglycemic dogs (47 +/- 10%). L-arginine prevented decreases in retrograde coronary collateral blood flow during hyperglycemia (100 +/- 5 and 95 +/- 6% of baseline at blood glucose concentrations of 400 and 600 mg/dl, respectively) and after coronary hypoperfusion and reperfusion (84 +/- 14%). The results suggest that hyperglycemia decreases retrograde coronary collateral blood flow by adversely affecting nitric oxide availability.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Arginine - pharmacology
- Collateral Circulation - drug effects
- Coronary Circulation - drug effects
- Disease Models, Animal - drug effects
- Dogs - drug effects
- Hyperglycemia - metabolism
- Microcirculation - drug effects
- Myocardial Ischemia - metabolism
- Myocardial Reperfusion Injury - metabolism
- Nitric Oxide - metabolism
- Research Support, Non-U.S. Gov't - metabolism
- Research Support, U.S. Gov't, P.H.S. - metabolism
- Find related publications in this database (Keywords)
- collateral circulation
- myocardial ischemia
- reperfusion injury