Medizinische Universität Graz - Research portal
Selected Publication:
Renner, W; Winkler, M; Hoffmann, C; Köppel, H; Seinost, G; Brodmann, M; Pilger, E.
The PlA1/A2 polymorphism of platelet glycoprotein IIIa is not associated with deep venous thrombosis.
Int Angiol. 2001; 20(2):148-151
Doi: 10.1016/S0021-9150(00)80093-3
Web of Science
PubMed
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FullText_MUG
- Leading authors Med Uni Graz
- Renner Wilfried
- Co-authors Med Uni Graz
- Brodmann Marianne
- Köppel Herwig
- Pilger Ernst
- Seinost Gerald
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- Abstract:
- BACKGROUND: Platelet glycoprotein (GP) IIb/IIIa, a fibrinogen and von Willebrand factor binding membrane receptor, has an important role in platelet aggregation. A common leucine33-proline polymorphism (PlA1/A2) of the gene encoding the GP IIIa subunit is associated with platelet reactivity and has been proposed as a risk factor for atherothrombotic disease. The aim of this study was to investigate the role of this polymorphism for deep venous thrombosis (DVT). METHODS: We performed a case-control study including 206 patients with documented DVT and a sex- and age-matched group of 310 control subjects. GP IIIa genotypes were determined by restriction fragment analysis of amplimers containing the polymorphic site. RESULTS: A1/A1, A1/A2 and A2/A2 genotypes were found in 67.0, 31.6 and 1.5 percent of patients and 72.3, 25.8 and 1.9 percent of controls (p=0.35), PlA2 allele frequencies were 0.17 in patients and 0.15 in controls (p=0.92). Odds ratio of the PlA2 allele for DVT was 1.21 (95 percent CI 0.85-1.71, p=0.29) and remained insignificant after adjustment for factor V Leiden and prothrombin 20210A genotypes (1.22, 95 percent CI 0.86-1.75, p=0.27). CONCLUSIONS: Our data suggest that the PlA1/A2 polymorphism of GP IIIa is not associated with DVT.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Antigens, Human Platelet - genetics
- Austria - genetics
- Case-Control Studies - genetics
- Epitopes - genetics
- Factor V - genetics
- Female - genetics
- Gene Frequency - genetics
- Genotype - genetics
- Humans - genetics
- Male - genetics
- Middle Aged - genetics
- Platelet Glycoprotein GPIIb-IIIa Complex - genetics
- Polymorphism, Genetic - genetics
- Predictive Value of Tests - genetics
- Prothrombin - genetics
- Pulmonary Embolism - genetics
- Venous Thrombosis - genetics
- Find related publications in this database (Keywords)
- risk factors
- venous thrombosis
- platelet glycoprotein GPIIb/IIIa complex polymorphism