Medizinische Universität Graz - Research portal
Selected Publication:
Stefan, H; Wang, Y; Kerling, F; Hopp, P; Zhou, D; Dienel, A; Feichtinger, M; Kirchner, A; Pauli, E.
Therapeutic intensive seizure analysis (TISA) in presurgical evaluation of Losigamone.
Acta Neurol Scand. 2001; 104(4):195-201
Doi: 10.1034%2Fj.1600-0404.2001.00371.x
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- Co-authors Med Uni Graz
- Feichtinger Michael
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- Abstract:
- OBJECTIVE: The new method TISA was used to evaluate Losigamone efficacy. METHODS: Sixteen patients with pharmacoresistant partial seizures undergoing presurgical evaluation were randomized in this double-blind, placebo-controlled, parallel-group Losigamone monotherapy study under continuous video-EEG monitoring. Duration (in s, of each seizure and each ictal sign), intensity (grade zero to three), N/24h (number of seizures and ictal signs per 24 h), D/24h (seconds per 24 h covered by seizures and ictal signs) and seizure free intervals were recorded. RESULTS: A total of 246 seizures were intensively analyzed. The duration and intensity of all seizures improved more in the active treatment group than in the placebo group. There was a statistically significant superiority in the duration of the seizure free interval in the Losigamone group. Ictal signs such as oro-alimentary automatisms and fumbling were improved during Losigamone treatment. CONCLUSION: Losigamone has a preferred inhibitory effect on propagated epileptic activity. TISA is a sensitive method for evaluation of the selective effects of AEDs.
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- Humans - pharmacology
- Male - pharmacology
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- Find related publications in this database (Keywords)
- seizure evaluation
- video-EEG monitoring
- ictal semiology