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Hofer, A; Kaddu, S; Seidl, H; Kerl, H; Wolf, P.
Collision of squamous-cell carcinoma with melanoma in situ in a child with xeroderma pigmentosum.
Dermatology. 2001; 203(1):66-69 Doi: 10.1159/000051708 (- Case Report)
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Leading authors Med Uni Graz: Hofer Angelika
Co-authors Med Uni Graz: Kaddu Steven; Kerl Helmut; Seidl Hannes; Wolf Peter
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Abstract:: Coexistence (collision) of two different neoplasms in the same lesion has previously been documented by several authors. In this report, we describe a 13-year-old boy with xeroderma pigmentosum presenting with squamous-cell carcinoma and melanoma arising at the same site on the nose. Histopathologically, the melanoma component of the lesion was located mainly eccentrically to the squamous-cell carcinoma component. Immunohistochemical stains confirmed the histopathologic findings. Mutations for p53 assessed using single-strand conformation polymorphism, and sequencing analysis revealed a CC-to-TT transition at codon 159 of the p53 gene in the squamous-cell component but not in the melanoma component. This finding suggests a possible role for UV in the pathogenesis of at least the squamous-cell component of the tumor. To the best of our knowledge, this is the first report of a collision tumor comprising squamous-cell carcinoma and melanoma arising in childhood.
Find related publications in this database (using NLM MeSH Indexing): Adolescent -; Carcinoma, Squamous Cell - complications; Humans - complications; Male - complications; Melanoma - complications; Neoplasms, Multiple Primary - pathology; Nose Neoplasms - complications; Skin Neoplasms - complications; Xeroderma Pigmentosum - complications
Find related publications in this database (Keywords): squamous-cell carcinoma; malignant melanoma; collision tumor; xeroderma pigmentosum; childhood