Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Pussinen, PJ; Metso, J; Malle, E; Barlage, S; Palosuo, T; Sattler, W; Schmitz, G; Jauhiainen, M.
The role of plasma phospholipid transfer protein (PLTP) in HDL remodeling in acute-phase patients.
Biochim Biophys Acta. 2001; 1533(2):153-163
Doi: 10.1016/S1388-1981(01)00153-6
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- Co-Autor*innen der Med Uni Graz
- Malle Ernst
- Sattler Wolfgang
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- Abstract:
- During reverse cholesterol transport plasma phospholipid transfer protein (PLTP) converts high density lipoprotein(3) (HDL(3)) into two new subpopulations, HDL(2)-like particles and pre-beta-HDL. The acute-phase response is accompanied with dramatic changes in lipid metabolism including alterations in HDL concentration, composition, and thereby its function as a substrate for HDL remodeling proteins in circulation. To evaluate how acute-phase HDL (AP-HDL) functions in PLTP-mediated HDL conversion, we collected plasma samples from patients with severe acute-phase response (n=17), and from healthy controls (n=30). Subsequently, total HDL (1.063
- Find related publications in this database (using NLM MeSH Indexing)
- Acute-Phase Reaction - blood
- Biological Transport - blood
- Carrier Proteins - blood
- Cholesterol Ester Transfer Proteins - blood
- Glycoproteins - blood
- Humans - blood
- Lipoproteins, HDL - chemistry
- Membrane Proteins - blood
- Phosphatidylcholine-Sterol O-Acyltransferase - blood
- Phospholipid Transfer Proteins - blood
- Ultracentrifugation - blood
- Find related publications in this database (Keywords)
- infection
- inflammation
- acute-phase high density lipoprotein
- high density lipoprotein conversion
- lipoprotein
- lipid transfer protein