Medizinische Universität Graz - Research portal
Selected Publication:
Pieber, D; Allport, VC; Bennett, PR.
Progesterone receptor isoform A inhibits isoform B-mediated transactivation in human amnion.
Eur J Pharmacol. 2001; 427(1):7-11
Doi: 10.1016/S0014-2999(01)01189-X
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- Pieber Doris
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- Abstract:
- Human amnion cells were transfected with progesterone receptor A and/or B, and the progesterone-dependent reporter construct, mouse mammary tumor virus promoter (MMTV), linked to a luciferase gene. In progesterone receptor B-expressing amnion that had been cultured before the onset of labour, treatment with progesterone resulted in an eightfold increase of the reporter activity, whereas in laboured cells, no such increase was seen. In contrast, progesterone receptor A was a weak activator of transcription in laboured and non-laboured amniocytes. When the isoforms A and B of the progesterone receptor were co-transfected, progesterone receptor A exhibited a marked inhibitory effect on progesterone receptor B-mediated transcription. These results show that progesterone receptors A and B function differentially, and progesterone receptor A is a transdominant repressor of progesterone receptor B-mediated transcription in human term amnion.
- Find related publications in this database (using NLM MeSH Indexing)
- Amnion - cytology
- Cells, Cultured - cytology
- Female - cytology
- Genetic Vectors - genetics
- Humans - genetics
- Luciferases - genetics
- Pregnancy - genetics
- Receptors, Progesterone - genetics
- Recombinant Fusion Proteins - genetics
- Trans-Activation (Genetics) - genetics
- Transcription, Genetic - genetics
- Find related publications in this database (Keywords)
- progesterone receptor
- progesterone withdrawal
- (human)
- amnion
- transfection