Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Fazekas, F; Strasser-Fuchs, S; Kollegger, H; Berger, T; Kristoferitsch, W; Schmidt, H; Enzinger, C; Schiefermeier, M; Schwarz, C; Kornek, B; Reindl, M; Huber, K; Grass, R; Wimmer, G; Vass, K; Pfeiffer, KH; Hartung, HP; Schmidt, R.
Apolipoprotein E epsilon 4 is associated with rapid progression of multiple sclerosis.
Neurology. 2001; 57(5):853-857
Doi: 10.1212/WNL.57.5.853
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Fazekas Franz
- Co-Autor*innen der Med Uni Graz
- Enzinger Christian
- Fuchs Siegrid
- Schmidt Helena
- Schmidt Reinhold
- Wimmer Gernot
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- Abstract:
- OBJECTIVE: The apolipoprotein E (APOE) polymorphism is known to impact on various neurologic disorders and has differential effects on the immune system and on CNS repair. Previous findings concerning a possible modulation of the clinical course of MS have been inconsistent, however. METHODS: In a cross-sectional study, the authors investigated 374 patients with clinically definite MS and a disease duration of at least 3 years and related their clinical and demographic findings to the allelic polymorphism of the APOE gene. The genotype distribution of patients with MS was compared with a cohort of 389 asymptomatic, randomly selected elderly volunteers. RESULTS: The authors found no significant differences in the distribution of genotypes between patients with MS and controls. However, patients with MS with the epsilon4 allele (n = 85) had a significantly higher progression index of disability (0.46 +/- 0.4 versus 0.33 +/- 0.26; p < 0.004) and a worse ranked MS severity score (5.1 +/- 1.9 versus 5.7 +/- 1.7; p = 0.05) than their non-epsilon4 counterparts, despite significantly more frequent long-term immunotherapy in epsilon4 carriers (74% versus 58%; p < 0.007). The annual relapse rate in epsilon4 carriers (0.87 +/- 0.56) was significantly higher than in patients with MS without an epsilon4 allele (0.71 +/- 0.47; p = 0.03). CONCLUSIONS: These results suggest no effect of the APOE genotype on susceptibility to MS, but indicate an association of the APOE epsilon4 allele with a more severe course of the disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Analysis of Variance -
- Apolipoprotein E4 -
- Apolipoproteins E - genetics
- Chi-Square Distribution -
- Cohort Studies -
- Cross-Sectional Studies -
- Disease Progression -
- Female -
- Genetic Markers - genetics
- Genotype -
- Humans -
- Male -
- Middle Aged -
- Multiple Sclerosis - genetics