Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Lobell, A; Weissert, R; Storch, MK; Svanholm, C; de Graaf, KL; Lassmann, H; Andersson, R; Olsson, T; Wigzell, H.
Vaccination with DNA encoding an immunodominant myelin basic protein peptide targeted to Fc of immunoglobulin G suppresses experimental autoimmune encephalomyelitis.
J Exp Med. 1998; 187(9):1543-1548
Doi: 10.1084/jem.187.9.1543
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Co-Autor*innen der Med Uni Graz
- Storch Maria
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- We explore here if vaccination with DNA encoding an autoantigenic peptide can suppress autoimmune disease. For this purpose we used experimental autoimmune encephalomyelitis (EAE), which is an autoaggressive disease in the central nervous system and an animal model for multiple sclerosis. Lewis rats were vaccinated with DNA encoding an encephalitogenic T cell epitope, guinea pig myelin basic protein peptide 68-85 (MBP68-85), before induction of EAE with MBP68-85 in complete Freund's adjuvant. Compared to vaccination with a control DNA construct, the vaccination suppressed clinical and histopathological signs of EAE, and reduced the interferon gamma production after challenge with MBP68-85. Targeting of the gene product to Fc of IgG was essential for this effect. There were no signs of a Th2 cytokine bias. Our data suggest that DNA vaccines encoding autoantigenic peptides may be useful tools in controlling autoimmune disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Autoimmune Diseases - immunology
- DNA - immunology
- Encephalomyelitis - immunology
- Guinea Pigs - immunology
- Immunoglobulin Fc Fragments - immunology
- Myelin Basic Proteins - immunology
- Peptide Fragments - immunology
- Plasmids - genetics
- Rats - genetics
- Rats, Inbred Lew - genetics
- T-Lymphocytes - immunology
- Vaccines, DNA - immunology