Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Wölfler, A; Caluba, HC; Abuja, PM; Dohr, G; Schauenstein, K; Liebmann, PM.
Prooxidant activity of melatonin promotes fas-induced cell death in human leukemic Jurkat cells.
FEBS Lett. 2001; 502(3):127-131
Doi: 10.1016/S0014-5793(01)02680-1
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- Führende Autor*innen der Med Uni Graz
- Liebmann-Holzmann Peter
- Wölfler Albert
- Co-Autor*innen der Med Uni Graz
- Abuja Peter Michael
- Dohr Gottfried
- Schauenstein Konrad
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- Abstract:
- The antioxidant activity of melatonin (MEL) has been considered to constitute part of its physiological as well as pharmacological effects. However, as described herein we found a profound prooxidant activity of micro- to millimolar concentrations of MEL in the human leukemic Jurkat cell line. This prooxidant effect was increased in glutathione-depleted cells and counteracted by antioxidants. As a consequence MEL promoted fas-induced cell death. These data therefore indicate that MEL may be a modulator of the cellular redox status, but does not necessarily act as an intracellular antioxidant.
- Find related publications in this database (using NLM MeSH Indexing)
- Antigens, CD95 - metabolism
- Antioxidants - pharmacology
- Apoptosis - drug effects
- Cell Survival - drug effects
- Glutathione - metabolism
- Humans - metabolism
- Hydrogen Peroxide - pharmacology
- Indicators and Reagents - pharmacology
- Jurkat Cells - metabolism
- Melatonin - pharmacology
- Oxidants - pharmacology
- Oxidation-Reduction - pharmacology
- Reactive Oxygen Species - metabolism
- Rhodamines - diagnostic use
- Find related publications in this database (Keywords)
- melatonin
- reactive oxygen species
- lymphocyte apoptosis
- cellular redox regulation