Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Frilling, A; Stavrou, GA; Mischinger, HJ; de Hemptinne, B; Rokkjaer, M; Klempnauer, J; Thörne, A; Gloor, B; Beckebaum, S; Ghaffar, MF; Broelsch, CE.
Effectiveness of a new carrier-bound fibrin sealant versus argon beamer as haemostatic agent during liver resection: a randomised prospective trial.
Langenbecks Arch Surg. 2005; 390(2):114-120
Doi: 10.1007/s00423-005-0543-x
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Mischinger Hans-Jörg
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- Abstract:
- Background and aims: A new carrier-bound fibrin sealant, TachoSil, is expected to be efficacious and safe as a haemostatic treatment in hepatic resection. Design: A prospective, randomised, open and controlled multicentre trial with intraoperative as well as postoperative assessment of efficacy and a 1 month follow-up period. Setting: Tertiary care centres. Patients/methods: One hundred and twenty-one patients requiring secondary haemostasis during planned liver resection. Patients with coagulation disorders and patients with persistent major bleeding after primary haemostatic measures were excluded. Intervention: Application of either carrier-bound fibrin sealant (n=59) or argon beamer (argon beam coagulator) (n=62) as secondary haemostatic treatment. Main outcome measure: Time to intraoperative haemostasis. Results: There was a significant superiority of TachoSil over argon beamer with regard to time to haemostasis (3.9 min, median 3.0, range 3-20 min vs 6.3 min, median 4.0, range 3-39 min) (P=0.0007). Haemoglobin concentration of drainage fluid was significantly lower on day 2 after surgery in TachoSil patients (1.1 mmol/l) than in argon beamer patients (2.3 mmol/l) (P=0.012). Overall, the frequency and causality of adverse events did not differ between the two treatment groups. Conclusion: TachoSil is superior to argon beamer in obtaining effective and fast intraoperative haemostasis. The safety data show TachoSil to be tolerable and safe for haemostatic treatment in liver resection.
- Find related publications in this database (using NLM MeSH Indexing)
- Drug Carriers -
- Fibrin Tissue Adhesive - therapeutic use
- Follow-Up Studies -
- Hemostasis, Surgical -
- Hemostatics - therapeutic use
- Hepatectomy -
- Humans -
- Laser Coagulation -
- Prospective Studies -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- liver resection
- new carrier-bound fibrin sealant