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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Aberer, E; Kahofer, P; Binder, B; Kinaciyan, T; Schauperl, H; Berghold, A.
Comparison of a two- or three-week regimen and a review of treatment of erythema migrans with phenoxymethylpenicillin.
DERMATOLOGY. 2006; 212(2): 160-167.
Doi: 10.1159/000090657
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Aberer Elisabeth
- Co-authors Med Uni Graz
- Berghold Andrea
- Binder Barbara
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- Abstract:
- BACKGROUND: A longer duration treatment is preferred in erythema migrans (EM) to prevent late complaints. OBJECTIVES: To determine whether 20 (20d-pt) or 14 days (14d-pt) of phenoxymethylpenicillin (PenV) have similar efficacy in treating EM and preventing further sequelae. PATIENTS AND METHODS: In a prospective double-centre study, 102 patients with EM were treated with PenV 1.5 million IU thrice daily for either 20 or 14 days and followed up for 12 months. RESULTS: The primary cure rate after treatment with PenV was 91.5% (79.6-97.6) for 20d-pt vs. 91.7% (77.5-98.2) for 14d-pt; p > 0.99). In 7 patients (4/20d-pt and 3/14d-pt), persistent or newly arising symptoms required retreatment. After 1 year, all patients were cured. The immune response showed no statistical difference between the treatment groups in the follow-up period. CONCLUSION: A 2-week treatment regimen of PenV seems to be as effective as a 3-week course with no statistical differences for clinical and serological findings after treatment.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Anti-Bacterial Agents - administration and dosage
- Antibodies, Anti-Idiotypic - immunology
- Double-Blind Method - immunology
- Drug Administration Schedule - immunology
- Enzyme-Linked Immunosorbent Assay - immunology
- Erythema - drug therapy
- Female - drug therapy
- Follow-Up Studies - drug therapy
- Humans - drug therapy
- Immunoglobulin G - immunology
- Immunoglobulin M - immunology
- Male - immunology
- Middle Aged - immunology
- Penicillin V - administration and dosage
- Prospective Studies - administration and dosage
- Time Factors - administration and dosage
- Treatment Outcome - administration and dosage
- Find related publications in this database (Keywords)
- erythema migrans
- Lyme borreliosis
- penicillin
- Borrelia burgdorferi