Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wang-Tilz, Y; Tilz, C; Wang, B; Tilz, GP; Stefan, H.
Influence of lamotrigine and topiramate on MDR1 expression in difficult-to-treat temporal lobe epilepsy.
Epilepsia. 2006; 47(2):233-239
Doi: 10.1111/j.1528-1167.2006.00414.x
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- Co-Autor*innen der Med Uni Graz
- Tilz Gernot
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- Abstract:
- Purpose: Overexpression of the multiple drug resistance gene 1 (MDR1) was quantified in brain tissue from Coriaria lactone (CL)-kindled Sprague-Dawley (SD) rats after treatment with lamotrigine (LTG) or topiramate (TPM) and compared with that found in rats treated with carbamazepine (CBZ) and valproate (VPA). Methods: Twenty-five CL-kindled SD rats were randomized into five groups (n = 5 for each group) to receive once-daily feeding of CBZ, VPA, TPM, and LTG as the monotherapy equivalent of maximum human adult dosage, or normal saline (NS control) for 1 month. The expression of P-gp in brain tissues of all rats was quantified by using an image analysis and measuring system (Image Pro-plus 4.0). Mean area and mean integrated optical density (mean IOD) of P-gp expression were calculated. In addition, the changes in seizure severity were analyzed via video-camera monitoring. Results: A significant decrease in the number and duration of seizures with antiepileptic drug (AED) treatment was observed in the TPM and LTG groups. The mean area and mean IOD of P-gp expression were highest in the CBZ group and next highest in the VPA group; much lower values were measured in the TPM and LTG groups, and the lowest in the NS control group (p < 0.05). Conclusions: TPM and LTG significantly inhibited seizures in this CL model. The expression of P-gp was not significantly increased by TPM or LTG treatment in this study.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Anticonvulsants - pharmacology Anticonvulsants - therapeutic use
- Brain - drug effects Brain - metabolism
- Carbamazepine - pharmacology
- Disease Models, Animal -
- Drug Resistance -
- Epilepsy, Temporal Lobe - chemically induced Epilepsy, Temporal Lobe - genetics Epilepsy, Temporal Lobe - prevention & control
- Fructose - analogs & derivatives Fructose - pharmacology
- Gene Expression - drug effects
- Genes, MDR - drug effects Genes, MDR - genetics
- Humans -
- Immunohistochemistry -
- Kindling, Neurologic - drug effects
- Lactones -
- Male -
- P-Glycoprotein - metabolism
- Random Allocation -
- Rats -
- Rats, Sprague-Dawley -
- Triazines - pharmacology
- Valproic Acid - pharmacology
- Find related publications in this database (Keywords)
- Coriaria lactone animal model
- pharmacoresistant temporal lobe epilepsy
- multidrug resistance gene 1 (MDR1)
- lamotrigine
- topiramate