Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mache, CJ; Schwinger, W; Spendel, S; Zach, O; Regauer, S; Ring, E.
Skin transplantation to monitor clinical donor-related tolerance in mixed hematopoietic chimerism.
PEDIATR TRANSPLANT. 2006; 10(1): 128-131.
Doi: 10.1111/j.1399-3046.2005.00412.x
(- Case Report)
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Mache Christoph
- Co-Autor*innen der Med Uni Graz
- Regauer Sigrid
- Ring Ekkehard
- Schwinger Wolfgang
- Spendel Stephan
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- Abstract:
- Mixed hematopoietic chimerism usually carries with it the tolerance to any other tissue from the same donor. Consequently, the establishment of a sustained chimerism may allow long-term acceptance of transplanted organs without immunosuppression. We report a girl with refractory severe aplastic anemia who developed low recipient level hematopoietic chimerism following transplantation of maternal highly purified CD34+ cells without prophylactic immunosuppression. Renal thrombotic microangiopathy led to chronic renal failure and she received skin allografts from her mother in view of a future kidney donation. The maternal skin grafts were accepted without immunosuppression and the hematopoietic chimerism remained stable. Skin transplantation may be a helpful and easily applicable tool to monitor donor-related tolerance in hematopoietic chimerism clinically. It should contribute to minimize the risks of subsequent solid organ transplantation from the same donor without immunosuppression.
- Find related publications in this database (using NLM MeSH Indexing)
- Anemia, Aplastic - surgery
- Child - surgery
- Chimerism - surgery
- Female - surgery
- Follow-Up Studies - surgery
- Graft Rejection - diagnosis
- Hematopoietic Stem Cell Transplantation - adverse effects
- Humans - adverse effects
- Kidney Failure, Chronic - etiology
- Kidney Transplantation - etiology
- Monitoring, Physiologic - methods
- Skin Transplantation - methods
- Find related publications in this database (Keywords)
- hematopoietic chimerism
- skin transplantation
- immunologic tolerance
- graft acceptance