Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Beubler, E; Badhri, P; Schirgi-Degen, A.
5-HT receptor antagonists and heat-stable Escherichia coli enterotoxin-induced effects in the rat.
Eur J Pharmacol. 1992; 219(3):445-450
Doi: 10.1016%2F0014-2999%2892%2990486-N
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- Führende Autor*innen der Med Uni Graz
- Beubler Eckhard
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- Abstract:
- The effect of heat-stable E. coli enterotoxin on intestinal fluid secretion is commonly considered to be mediated by stimulation of mucosal cyclic guanosine monophosphate (cGMP). It was demonstrated recently that 5-hydroxytryptamine (5-HT) acts as an important mediator in cholera toxin-induced fluid secretion. To elucidate the possible involvement of 5-HT in the secretory response to heat-stable E. coli enterotoxin, in vivo experiments were performed in the rat jejunum. The inhibitory effects of the 5-HT2 receptor antagonist ketanserin, the 5-HT3 receptor antagonist tropisetron and indomethacin were studied in heat-stable E. coli enterotoxin-induced fluid secretion. Tropisetron and ketanserin (100 micrograms/kg each) alone only partially reduced the secretory effect of the toxin. However, in combination, the two blockers (100 plus 100 micrograms/kg) significantly reduced and at 200 plus 200 micrograms/kg totally abolished heat-stable E. coli enterotoxin-induced secretion without influencing the enterotoxin-induced increase in cGMP. Pretreatment with indomethacin (10 mg/kg) reduced the secretory response to the enterotoxin by about 50%. These results support the concept that 5-HT is an important mediator in intestinal fluid secretion induced by heat-stable E. coli enterotoxin. The enterotoxin may use 5-HT to stimulate prostaglandin formation via 5-HT2 receptors and to activate neuronal structures via 5-HT3 receptors.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Bacterial Toxins - pharmacology
- Cyclic GMP - biosynthesis
- Enterotoxins - pharmacology
- Female - pharmacology
- Indoles - administration and dosage
- Indomethacin - administration and dosage
- Injections, Subcutaneous - administration and dosage
- Intestinal Mucosa - chemistry
- Jejunum - drug effects
- Ketanserin - administration and dosage
- Rats - administration and dosage
- Rats, Sprague-Dawley - administration and dosage
- Serotonin Antagonists - administration and dosage
- Find related publications in this database (Keywords)
- CGMP
- Escherichia-Coli Enterotoxin (Heat-Stable)
- 5-HT(5-Hydroxytryptamine
- Serotonin)
- Indomethacin
- Intestinal Secretion
- Ketanserin
- Tropisetron