Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Stefferl, A; Storch, MK; Linington, C; Stadelmann, C; Lassmann, H; Pohl, T; Holsboer, F; Tilders, FJ; Reul, JM.
Disease progression in chronic relapsing experimental allergic encephalomyelitis is associated with reduced inflammation-driven production of corticosterone.
Endocrinology. 2001; 142(8):3616-3624
Doi: 10.1210/en.142.8.3616
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- Co-Autor*innen der Med Uni Graz
- Storch Maria
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- Abstract:
- In this study, we demonstrate that disruption of neuroendocrine signaling is a major factor driving disease progression in myelin oligodendrocyte glycoprotein-induced chronic relapsing experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. Although the initial episode of chronic relapsing experimental autoimmune encephalomyelitis is associated with a robust hypothalamic-pituitary-adrenocortical axis response, we show that subsequent disease progression is associated with a selective desensitization of hypothalamic-pituitary-adrenocortical responsiveness to inflammatory mediators. Inflammatory activity in the central nervous system during relapse is therefore unable to produce an endogenous immunosuppressive corticosterone response, and disease progresses into an ultimately lethal phase. However, disease progression is inhibited if the circulating corticosterone level is maintained at levels seen during the initial phase of disease. The effect of hypothalamic-pituitary-adrenocortical axis desensitization on the clinical course of experimental autoimmune encephalomyelitis is aggravated by a marked reduction in proinflammatory cytokine synthesis in the central nervous system in the later stages of disease, reflecting an increasing involvement of antibody, rather than T cell-dependent effector mechanisms, in disease pathogenesis, with time. Thus, our data indicate that distinct immune-endocrine effects play a decisive role in determining disease progression in multiple sclerosis, a concept supported by reports that a subpopulation of multiple sclerosis patients shows evidence of hypothalamic-pituitary-adrenocortical axis desensitization.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Autoantibodies - analysis
- Chronic Disease - analysis
- Corticosterone - antagonists and inhibitors
- Cytokines - metabolism
- Disease Progression - metabolism
- Encephalomyelitis, Autoimmune, Experimental - immunology
- Female - immunology
- Hypothalamo-Hypophyseal System - physiopathology
- Inflammation Mediators - metabolism
- Myelin-Associated Glycoprotein - immunology
- Pituitary-Adrenal System - physiopathology
- Rats - physiopathology
- Rats, Inbred Strains - physiopathology
- Receptors, Steroid - metabolism
- Recurrence - metabolism
- Remission Induction - metabolism
- Spinal Cord - metabolism
- Time Factors - metabolism