Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Schmidt, R; Schmidt, H; Fazekas, F; Launer, LJ; Niederkorn, K; Kapeller, P; Lechner, A; Kostner, GM.
Angiotensinogen polymorphism M235T, carotid atherosclerosis, and small-vessel disease-related cerebral abnormalities.
Hypertension. 2001; 38(1):110-115
Doi: 10.1161/01.HYP.38.1.110
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- Führende Autor*innen der Med Uni Graz
- Schmidt Reinhold
- Co-Autor*innen der Med Uni Graz
- Fazekas Franz
- Kapeller Peter
- Kostner Gerhard
- Niederkorn Kurt
- Schmidt Helena
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- Abstract:
- The angiotensinogen M235T polymorphism has been linked to hypertension and cardiovascular disease. We studied the role of this polymorphism as a risk factor for carotid atherosclerosis and small-vessel disease-related brain abnormalities. A total of 431 randomly selected community-dwelling subjects without clinical evidence for strokes underwent angiotensinogen genotyping and carotid Duplex scanning; 1.5-T brain magnetic resonance imaging (MRI) was done in 396 individuals. At 3-year follow-up, we reexamined 343 and 267 study participants by ultrasound and brain MRI, respectively. Carotid atherosclerosis was graded on a 5-point scale. Small-vessel disease-related brain abnormalities were deep or subcortical white matter lesions or lacunes. Progression of carotid atherosclerosis and MRI findings was rated by direct imaging comparison by 3 independent raters. The M/M, M/T, and T/T genotypes were seen in 20.9%, 52.9%, and 18.1% of subjects, respectively. The M235T polymorphism was neither associated with baseline carotid findings nor with progression of carotid atherosclerosis. There was a trend toward more frequent small-vessel disease-related MRI abnormalities in the T/T than in the other genotypes at the baseline examination. Progression of brain lesions occurred significantly more commonly in T/T than in M/M and M/T carriers (P<0.001). Logistic regression analysis identified the T/T genotype (odds ratio, 3.19; P=0.002) and arterial hypertension (odds ratio, 3.06; P=0.03) as significant independent predictors of lesion progression. These data suggest that the angiotensinogen T/T genotype at position 235 is a genetic marker for brain lesions from and progression of small vessel disease but not for extracranial carotid atherosclerosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Angiotensinogen - genetics
- Blood Vessels - genetics
- Carotid Artery Diseases - genetics
- Female - genetics
- Gene Frequency - genetics
- Genotype - genetics
- Humans - genetics
- Male - genetics
- Middle Aged - genetics
- Polymorphism, Genetic - genetics
- Risk Factors - genetics
- Telencephalon - genetics
- Find related publications in this database (Keywords)
- angiotensinogen
- genetics
- carotid arteries
- atherosclerosis
- vessels