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Selected Publication:
Siebenhofer, A; Meinitzer, A; Brandmair, J; Plank, J; Pieber, TR.
Variability of glomerular filtration rate estimation using single injection methods in Type 1 diabetic patients.
Diabet Med. 2001; 18(6):464-468
Doi: 10.1046%2Fj.1464-5491.2001.00508.x
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- Leading authors Med Uni Graz
- Siebenhofer-Kroitzsch Andrea
- Co-authors Med Uni Graz
- Meinitzer Andreas
- Pieber Thomas
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- Abstract:
- AIM: Single-injection inulin clearance (SIIC) methods without urine collection have often been compared with classical constant-infusion inulin clearance methods. Therefore, we used repeated SIIC measurements to prove the hypothesis of a possible overestimation or variability of inulin clearance in Type 1 diabetic patients. METHODS: Two SIIC periods, glomerular filtration rate 1 and 2 (GFR 1, GFR 2) were performed consecutively on the same day. In diabetic patients, GFR 3 was measured several days later at the same time of day as the GFR 1 had been done. The calculation used a two-compartment modelling system (TCM) which showed excellent agreement to ratio of dose over area under the curve (D/AUC) calculation. RESULTS: Twelve normotensive Type 1 diabetic patients (mean and SD), age 39 (10.7) years, diabetes duration 20 (10.7) years, HbA1c 8.5% (0.82%), albuminuria 13.8 (15.7) mg/24 h and six controls, age 26 (2.6) years were examined. Healthy controls showed an excellent repeatability between GFR 1 111.8 (11.44) and GFR 2 110.8 (11.41) ml.min-1.1.73 m2-1. However, in diabetic patients there was a highly significant decrease between GFR 1 129.4 (11.86) and GFR 2 118.1 (13.05) ml.min-1.1.73 m2-1. GFR 1 with 129.4 (11.86) ml.min-1.1.73 m2-1 did not differ significantly from GFR 3 with 129.9 (12.40) ml.min-1.1.73 m2-1 in diabetic patients (P < 0.839). CONCLUSIONS: In contrast to normal subjects, in Type 1 diabetic patients single-injection inulin clearance technique showed a clinically relevant decrease in GFR on two repeated measurements on the same day. Overestimation of GFR by the first inulin clearance may be caused by incomplete inulin distribution in the slow compartment. Diabet. Med. 18, 464-468 (2001)
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Albuminuria -
- Area Under Curve -
- Blood Glucose - metabolism
- Blood Pressure - metabolism
- Diabetes Mellitus, Type 1 - blood
- Female - blood
- Glomerular Filtration Rate - blood
- Hemoglobin A, Glycosylated - analysis
- Humans - analysis
- Infusions, Intravenous - analysis
- Inulin - administration and dosage
- Kidney Function Tests - methods
- Male - methods
- Models, Biological - methods
- Multivariate Analysis - methods
- Reference Values - methods
- Reproducibility of Results - methods
- Find related publications in this database (Keywords)
- distribution in slow compartment
- glomerular filtration rate
- overestimation
- single-injection inulin clearance
- Type 1 diabetes