Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Jagoditsch, M; Pertl, A; Jatzko, GR; Denk, H; Stettner, HM.
Long-term outcome of stomach carcinoma achieved in an Austrian standard hospital with an oncologic focus
Chirurg. 2001; 72(7):822-831
Doi: 10.1007/s001040170111
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- Co-Autor*innen der Med Uni Graz
- Denk Helmut
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- Abstract:
- INTRODUCTION: Although two large prospective and randomized planned European studies failed to show any benefit of radical D2 lymphadenectomy for gastric cancer, the value of radical lymphadenectomy is still a matter of controversy. METHODS: A radical surgical approach principally using D2, D3 lymphadenectomy, as defined by the Japanese Research Society for Gastric Cancer, has been prospectively performed since January 1984. Out of 729 patients with gastric cancer, 521 were surgically treated for potential cure between 1984 and 31 December, 1998. Clinical, histopathological and surgical factors were evaluated for their influence on long-term survival by means of univariate and multivariate analysis. RESULTS: Tumor-specific 5- and 10-year survival rates for all patients were 58.5% and 57.5% for patients who underwent tumor resection 59% and 58%. For operated patients upon with the aim of achieving cures, the tumor-specific 5- and 10-year survival rates were 63.3% and 62.2% and the median survival time was more than 144 months. Postoperative hospital mortality was 7.7%, 4.6% for R0 resected patients, 8.6% for R1,2 resected patients and 21.3% for those undergoing palliative procedures. Multivariate analysis using the Cox model identified an age older than 65, total gastrectomy as well as high pN- and pT category as detrimental factors with an independent influence on survival. CONCLUSION: After updating the long-term results of gastric cancer, as already published earlier, it is impressively obvious that also in a European setting of gastric cancer patients, with a presupposed appropriate surgical technique and experience, very constant cure rates are achievable with comparatively low mortality and morbidity.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenocarcinoma - mortality
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- Carcinoma - mortality
- Follow-Up Studies - mortality
- Gastrectomy - mortality
- Hospital Mortality - mortality
- Hospitals, General - mortality
- Humans - mortality
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- Find related publications in this database (Keywords)
- gastric cancer
- radical D2
- lymphadenectomy
- 5-and 10-year survival rates
- Cox-model