Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Brasch, J; Henseler, T; Aberer, W; Fuchs, T; Hoeck, U; Kreilgård, B; German Contact Dermatitis Research Group.
Patch testing of nickel sulfate and potassium dichromate with a standardized ready-to-use test system gives highly reproducible results: a double-blind multicentre study.
Acta Derm Venereol. 2001; 81(2):122-124
Doi: 10.1080%2F00015550152384263
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- Co-Autor*innen der Med Uni Graz
- Aberer Werner
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- Abstract:
- There is still some doubt about the reproducibility of patch tests. A sound assessment needs optimized and unbiased studies. This study analysed the results of a double-blind multicentre study with nickel sulfate and potassium dichromate patch tests attached synchronously to both sides of the back of patients with a history of nickel allergy, conducted with a highly standardized randomized test system (TRUE-test). Out of 589 patients tested, a total of 388 had responded with allergic reactions to nickel sulfate and 130 to potassium dichromate. The reproducibility of positive nickel (dichromate) patch tests was 99.2% (90.8%). The reaction index was also calculated, which relates the number of allergic reactions obtained with a test preparation to the number of questionable and irritant reactions; the reaction index can range from -1 (questionable and irritant reactions only occur) to 1 (allergic reactions only occur). For nickel sulfate the reaction index was 0.91, but it was only 0.23 for potassium dichromate, as a result of considerably more questionable reactions. In conclusion, a highly synchronous reproducibility of results can be achieved by using a well-standardized patch-test system, especially with nickel sulfate. However, distinct allergens and test systems need to be evaluated separately.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Coloring Agents - diagnostic use
- Double-Blind Method - diagnostic use
- Female - diagnostic use
- Humans - diagnostic use
- Hypersensitivity - diagnosis
- Irritants - diagnostic use
- Male - diagnostic use
- Middle Aged - diagnostic use
- Nickel - diagnostic use
- Patch Tests - methods
- Potassium Dichromate - diagnostic use
- Reproducibility of Results - diagnostic use
- Find related publications in this database (Keywords)
- patch-test reproducibility
- patch-test methods
- reaction index