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Selected Publication:
Hauser, AC; Hagen, W; Rehak, PH; Buchmayer, H; Födinger, M; Papagiannopoulos, M; Bieglmayer, C; Apsner, R; Köller, E; Ignatescu, M; Hörl, WH; Sunder-Plassmann, G.
Efficacy of folinic versus folic acid for the correction of hyperhomocysteinemia in hemodialysis patients.
Am J Kidney Dis. 2001; 37(4):758-765
Doi: 10.1016/S0272-6386(01)80125-6
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- Co-authors Med Uni Graz
- Rehak Peter
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- Abstract:
- The effectiveness of intravenous folinic acid or intravenous folic acid for the treatment of hyperhomocysteinemia of hemodialysis patients is unknown. In a randomized, controlled, double-blind trial, 66 hemodialysis patients were administered either 15 mg of folic acid or an equimolar amount (16.1 mg) of folinic acid intravenously three times weekly. Normalization of total homocysteine (tHcy) plasma levels after 4 weeks of treatment was achieved in 10 patients (30.3%) in the folic-acid group and 6 patients (18.2%; P: = 0.389) in the folinic-acid group (normalization at any time during the study period in 39.4% and 33.3% of the patients; P: = 0.798). The relative reduction in tHcy plasma levels at week 4 was 32.2% in the folic-acid group and 34.1% in the folinic-acid group. A high baseline tHcy plasma concentration (P: = 0.00001), methylenetetrahydrofolate reductase (MTHFR) 677TT/1298AA genotype (P: = 0.03540), and low red blood cell folate concentrations (P: = 0.02285) were associated with a better relative response to treatment. Normalization of tHcy plasma levels was dependent on a lower baseline tHcy level (P: = 0.01976), younger age (P: = 0.00896), and MTHFR 677TT/1298AA or 677CT/1298AC genotypes (P: = 0.00208 and P: = 0.02320, respectively). A 4-week course of intravenous folinic acid is not superior to intravenous folic acid in reducing elevated tHcy plasma levels in hemodialysis patients. The response to treatment is predicted by tHcy plasma level, red blood cell folate content, and MTHFR genotype.
- Find related publications in this database (using NLM MeSH Indexing)
- Double-Blind Method -
- Drug Administration Schedule -
- Erythrocytes - chemistry
- Female -
- Folic Acid - administration & dosage
- Genotype -
- Homocysteine - blood
- Humans -
- Hyperhomocysteinemia - blood
- Infusions, Intravenous -
- Leucovorin - administration & dosage
- Male -
- Methylenetetrahydrofolate Reductase (NADPH2) -
- Middle Aged -
- Oxidoreductases Acting on CH-NH Group Donors - blood
- Pyridoxine - blood
- Renal Dialysis -
- Treatment Outcome -
- Vitamin B 12 - blood
- Find related publications in this database (Keywords)
- total homocysteine (tHcy)
- methylenetetrahydrofolate reductase (MTHFR)
- folic acid
- folinic acid
- hemodialysis (HD)
- folate
- vitamin B-12
- vitamin B-6