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Selected Publication:
Weger, M; Stanger, O; Deutschmann, H; Simon, M; Renner, W; Schmut, O; Semmelrock, J; Haas, A.
Hyperhomocyst(e)inaemia, but not MTHFR C677T mutation, as a risk factor for non-arteritic ischaemic optic neuropathy.
Br J Ophthalmol. 2001; 85(7):803-806
Doi: 10.1136%2Fbjo.85.7.803
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- Leading authors Med Uni Graz
- Weger Martin
- Co-authors Med Uni Graz
- Deutschmann Hannes
- Haas Anton
- Renner Wilfried
- Schmut Otto
- Semmelrock Hans-Jürgen
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- Abstract:
- BACKGROUND/AIMS: Hyperhomocyst(e)inaemia has been identified as a strong risk factor for stroke, myocardial infarction, and deep vein thrombosis. A point mutation of methylene tetrahydrofolate reductase (MTHFR C677T) has been associated with increased plasma homocyst(e)ine levels. To investigate whether hyperhomocyst(e)inaemia and/or MTHFR C677T mutation are associated with non-arteritic ischaemic optic neuropathy (NAION), a case-control study including 59 consecutive patients with NAION and 59 controls matched for age and sex was performed. METHODS: Fasting plasma homocyst(e)ine levels, MTHFR C677T genotypes, and plasma levels of folate and vitamin B-12 were determined. RESULTS: Mean plasma homocyst(e)ine levels were significantly higher in patients than in controls (11.8 (SD 5.7) micromol/l v 9.8 (2.5) micromol/l, p = 0.02). The odds ratio for patients with homocyst(e)ine levels exceeding the 95th percentile of control homocyst(e)ine levels was 5.8 (95% CI 1.5-21.4). Mean plasma folate levels were significantly lower in patients than in controls (4.3 (1.7) ng/ml v 5.5 (1.9) ng/ml, p = 0.001), whereas plasma vitamin B-12 levels did not differ significantly. Prevalence of the MTHFR C677T mutation was not significantly increased in patients with NAION compared with controls. CONCLUSION: These results suggest that hyperhomocyst(e)inaemia, but not MTHFR C677T mutation is associated with NAION. Determination of plasma homocyst(e)ine levels might be of diagnostic value in patients with NAION.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Biological Markers - blood
- Case-Control Studies - blood
- Female - blood
- Folic Acid - blood
- Humans - blood
- Hyperhomocysteinemia - blood
- Male - blood
- Methylenetetrahydrofolate Reductase (NADPH2) - blood
- Middle Aged - blood
- Optic Neuropathy, Ischemic - blood
- Oxidoreductases Acting on CH-NH Group Donors - genetics
- Point Mutation - genetics
- Risk Factors - genetics
- Vitamin B 12 - blood