Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Cvirn, G; Gallistl, S; Muntean, W.
Alpha-2-macroglobulin inhibits the anticoagulant action of activated protein C in cord and adult plasma.
Haemostasis. 2001; 31(1):1-11
Doi: 10.1159/000048038
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- Führende Autor*innen der Med Uni Graz
- Cvirn Gerhard
- Co-Autor*innen der Med Uni Graz
- Gallistl Siegfried
- Muntean Eugen
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- Abstract:
- Healthy newborns have a very low risk of thrombosis. It has been suggested that this is partly due to the anticoagulant effect of alpha-2-macroglobulin (a2-M). This broad-spectrum protease binding glycoprotein is physiologically elevated in newborns over adult values and has been shown to complex generated alpha-thrombin. In our present study, we point out that a2-M also acts as a procoagulant by inhibiting activated protein C (APC). In all experiments performed in cord and adult plasma the anticoagulant action of APC was diminished in a dose-dependent manner when a2-M levels were successively elevated, reflected in increased thrombin potential (TP), and enhanced at low a2-M levels, reflected in decreased TP.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Anticoagulants - antagonists and inhibitors
- Blood Coagulation Tests - antagonists and inhibitors
- Dose-Response Relationship, Drug - antagonists and inhibitors
- Fetal Blood - chemistry
- Hemostatics - metabolism
- Humans - metabolism
- Kinetics - metabolism
- Peptide Fragments - drug effects
- Protein C - antagonists and inhibitors
- Prothrombin - drug effects
- Thrombin - drug effects
- Thrombophilia - blood
- alpha-Macroglobulins - pharmacology
- Find related publications in this database (Keywords)
- activated protein C
- alpha-2-macroglobulin
- thrombin potential
- prothrombin activation