Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Sudi, KM; Gallistl, S; Tröbinger, M; Weinhandl, G; Aigner, R; Payerl, D; Tafeit, E; Möller, R; Borkenstein, MH.
Subcutaneous adipose tissue layers as a stable correlate of leptin in response to short term energy restriction in obese girls.
Int J Obes Relat Metab Disord. 2001; 25 Suppl 1(6):S43-S45
Doi: 10.1038/sj.ijo.0801697
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- Co-Autor*innen der Med Uni Graz
- Aigner Reingard
- Borkenstein Helmuth Martin
- Gallistl Siegfried
- Möller Reinhard
- Payerl Doris
- Tafeit Erwin
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- Abstract:
- AIMS: We studied the relationship of subcutaneous adipose tissue layers (SAT-layers) measured at 15 specified body sites with leptin before and after a weight loss program for three weeks. SUBJECTS AND METHODS: In 70 obese girls, SAT-layers were measured by means of the optical device, lipometer. Fat mass (FM) was estimated by means of bioelectrical impedance. RESULTS: At the beginning of the study, all estimates of adiposity, insulin, and SAT-layers from the upper body (from 1-neck to 6-lateral chest) were correlated to leptin at a P-value of<0.0001. Percentage FM together with SAT-layer 4-upper back and insulin explained 75% of the variation in leptin (P<0.0001). After three weeks, estimates of adiposity and leptin were reduced (all P<0.0001). Most SAT-layers were reduced, but SAT-layers 8-lower abdomen and 9-lower back were significantly increased. Changes in leptin were best explained by initial leptin, but percentage change (Delta) in insulin, Delta SAT-layer 1-neck, and Delta SAT-layer 3-biceps contributed to the Delta leptin (adj. r(2)=0.47, P<0.0001). In the weight-reduced state, circulating leptin was best explained by three SAT-layers and insulin (adj. r(2)=0.67, P<0.0001). DISCUSSION: The results suggest that Delta changes in leptin are attributable to changes in the endocrine state and subcutaneous fat, and SAT-layers may serve as a stable correlate of leptin in the weight-reduced state.
- Find related publications in this database (using NLM MeSH Indexing)
- Adipose Tissue - metabolism
- Body Mass Index - metabolism
- Body Weight - physiology
- Child - physiology
- Diet, Reducing - physiology
- Electric Impedance - physiology
- Female - physiology
- Humans - physiology
- Insulin - blood
- Leptin - blood
- Obesity - metabolism
- Find related publications in this database (Keywords)
- leptin
- subcutaneous adipose tissue layers
- obesity
- girls
- lipometer