Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Eder, HG; Leber, KA; Eustacchio, S; Pendl, G.
The role of gamma knife radiosurgery in children.
Childs Nerv Syst. 2001; 17(6):341-346
Doi: 10.1007%2Fs003810000435
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Eder Hans
- Co-Autor*innen der Med Uni Graz
- Eustacchio Sandro
- Leber Klaus
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- Abstract:
- OBJECTS: Despite advances in microneurosurgery, the surgical management of deep-seated lesions is still associated with a high risk. Gamma knife radiosurgery (GKRS), however, has improved the outcome of cerebral tumors and arteriovenous malformations (AVMs) in delicate areas. METHODS: Between March 1992 and June 1998, 50 children (age 1-16 years) with intracranial lesions were treated with GKRS. There were 12 low-grade gliomas, 12 high-grade gliomas, 7 craniopharyngiomas, 3 hamartomas, 2 meningiomas of the skull base, 2 vestibular schwannomas, 1 pituitary adenoma, 1 choroid plexus papilloma, and 10 AVMs. The mean size of the pathologies was 4.6 cm3 (range: 0.21-25.5 cm3). A mean marginal dose of 16 Gy (8-25 Gy) was applied to a mean isodose surface of 50% (35-90%). Clinical and neuroradiological follow-up were analyzed for outcome. Follow-up periods of 45 of these patients ranged from 8 to 79 months (mean 36 months); 5 patients were lost to follow-up. Neoplasms decreased in size in 15 cases (41%), remained unchanged in 13 patients (35%), and increased in 9 cases (24%). AVMs obliterated in 3 children (38%) within 24 months. Neurological follow-up demonstrated improved clinical status in 7 patients (15.5%), stable neurological status in 31 cases (69%) and clinical deterioration in 7 patients (15.5%). The treatment was well tolerated and no complications occurred. CONCLUSIONS: GKRS represents a safe and effective treatment option for benign neoplasms or AVMs in pediatric patients and may extend survival times of children with malignant lesions.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Brain Neoplasms - surgery
- Child - surgery
- Child, Preschool - surgery
- Female - surgery
- Follow-Up Studies - surgery
- Humans - surgery
- Infant - surgery
- Intracranial Arteriovenous Malformations - surgery
- Male - surgery
- Neurologic Examination - surgery
- Postoperative Complications - diagnosis
- Radiosurgery - diagnosis
- Find related publications in this database (Keywords)
- gamma knife
- radiosurgery
- children
- brain tumor
- arteriovenous malformation