Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Cerwenka, H; Aigner, R; Bacher, H; Werkgartner, G; el-Shabrawi, A; Quehenberger, F; Mischinger, HJ.
Pancreatitis-associated protein (PAP) in patients with pancreatic cancer.
Anticancer Res. 2001; 21(2B):1471-1474
Web of Science
PubMed
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Cerwenka Herwig
- Co-Autor*innen der Med Uni Graz
- Aigner Reingard
- Bacher Heinz
- Mischinger Hans-Jörg
- Quehenberger Franz
- Werkgartner Georg
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- Abstract:
- Background: Pancreatitis-associated protein (PAP) is known as a marker for pancreatitis and cystic fibrosis. The aim of our study was to evaluate PAP in patients with pancreatic cancer, to assess its con elation to the extent of the disease and to compare it to CA19-9. Patients and Methods: This prospective study comprised 75 individuals. Thirty had pancreatic cancer, 30 were healthy controls and 25 had benign lesions of the pancreas. PAP was determined by enzyme-linked immunosorbent assay. Statistical analysis was by Wilcoxon test and Spearman con elation coefficients. Results: As compared to healthy individuals and using a cut-off of 18 mug/l corresponding to a sensitivity of 90%, the specificity of PAP for pancreatic cancel was 82.8%. PRP elevation in cancel patients could not be explained by concomitant pancreatitis (p=0.649). PAP did not show correlation to tumour, size (p=0.14), T-stages (p=0.706) or tumour grading (p=0.105), bur was significantly correlated to the over all extent of the disease according to the UICC stages (p=0.002). No con elation between PAP and CA19-9 was seen. Jaundice was not found to influence PAP values (p=0.4). Conclusion: Elevation of PAP in patients with pancreatic cancer. is not merely explainable by concomitant pancreatitis, but seems to be due to increased PAP production by the cancer cells and is also correlated to tumour load as expressed by the UICC stages.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute-Phase Proteins - analysis
- Antigens, Neoplasm -
- CA-19-9 Antigen - blood
- Humans -
- Lectins, C-Type -
- Pancreatic Diseases - blood
- Pancreatic Neoplasms - blood Pancreatic Neoplasms - physiopathology
- Prospective Studies -
- Tumor Markers, Biological - blood
- Find related publications in this database (Keywords)
- pancreatitis-associated protein
- PAP
- pancreatic cancer
- pancreatitis
- CA19-9