Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Greenleaf, JE; Hinghofer-Szalkay, H; Rössler, A; Farrell, PA; Loomis, JL; Fedele, MJ; West, J; Cowell, SA.
Plasma sodium-osmotic dissociation and hormonal interaction with drinking-induced hypervolemia at 2800 m altitude.
Aviat Space Environ Med. 2001; 72(6):522-528
Web of Science
PubMed
- Co-Autor*innen der Med Uni Graz
- Hinghofer-Szalkay Helmut
- Rössler Andreas
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- Abstract:
- PURPOSE: To study hormonal factors that may account for the dissociation between beverage-induced plasma sodium p[Na+] and osmotic p[Osm] concentrations that appear to refute the high theoretical correlation between p[Na+] and p[Osm]. METHODS: Ten men (24 +/- SD 3 yr of age) sat reclining (head up) for 12 h in a chamber (21-23 degrees C dry bulb, 25-33% relative humidity) at 2800 m (9184 ft, 539 mm Hg) altitude (ALT), and at 321 m (1053 ft, 732 mm Hg) on the ground (GND). During 1000-1030 hours they consumed 3 fluids (12 ml x kg(-1),X = 948 ml x d(-1)) with large differences in sodium and osmotic contents: AstroAde (AA) with 185 mEq x L(-1) Na+ and 283 mOsm x kg(-1), Performance 1 (Shaklee) (P1) with 22 mEq x L(-1) Na+ and 365 mOsm kg(-1), or H2O at ALT; and only H2O on the GND. RESULTS: After drinking: plasma volume (PV) increased at 1200 hours by 8.3% (p < 0.05) with AA but was not significantly (NS) changed in the other sessions (Xdelta = +0.9%, range -0.9 to 2.8%); p[Na+] and p[Osm] were unchanged. Urinary rates and free-water clearances were attenuated with AA and P1 vs. those with H2O. Correlations between and among p[Na+] and p[Osm] suggest that the pNa+ ion is more tightly controlled than pOsm; and that there was no clear hormonal response that could account for this dissociation from theoretical considerations. CONCLUSIONS: There is significant dissociation between plasma sodium and osmotic concentrations after fluid intake. Induction and maintenance of hypervolemia requires increased (near isotonic) drink Na+ osmols rather than increased non-ionic osmols.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Altitude -
- Angiotensin II - physiology
- Drinking Behavior - physiology
- Humans - physiology
- Male - physiology
- Osmolar Concentration - physiology
- Plasma Volume - drug effects
- Rehydration Solutions - adverse effects
- Renin - physiology
- Sodium - blood
- Thirst - physiology
- Vasopressins - physiology
- Water - adverse effects
- Water Intoxication - etiology
- Find related publications in this database (Keywords)
- flight fatigue
- fluid intake
- flight
- stress