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Kütting, B; Bonsmann, G; Metze, D; Luger, TA; Cerroni, L.
Borrelia burgdorferi-associated primary cutaneous B cell lymphoma: complete clearing of skin lesions after antibiotic pulse therapy or intralesional injection of interferon alfa-2a.
J Am Acad Dermatol. 1997; 36(2 Pt 2):311-314 Doi: 10.1016/S0190-9622(97)80405-7 (- Case Report)
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Co-authors Med Uni Graz: Cerroni Lorenzo
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Abstract:: We report two patients with low-grade malignant primary cutaneous B cell lymphoma in association with Borrelia burgdorferi infection. Extracutaneous manifestations were ruled out by standard staging procedures. Infection with Borrelia burgdorferi was confirmed by cultivation from lesional skin in both patients. In the first patient skin lesions cleared completely after pulse therapy with cefotaxime, whereas in the second patient antibiotic treatment failed. In this patient, however, skin lesions completely cleared after intralesional injection of interferon alfa-2a. Antibiotic treatment or intralesional injection of interferon alfa-2a should be considered as a first-line treatment of Borrelia burgdorferi-associated primary cutaneous B cell lymphoma before more aggressive conventional therapeutic modalities (e.g., radiation therapy) are applied.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Borrelia burgdorferi Group - isolation and purification; Cefotaxime - administration and dosage; Ceftriaxone - administration and dosage; Doxycycline - administration and dosage; Drug Administration Schedule - administration and dosage; Drug Therapy, Combination - administration and dosage; Humans - administration and dosage; Injections, Intralesional - administration and dosage; Interferon Alfa-2a - administration and dosage; Lyme Disease - complications; Lymphoma, B-Cell - etiology; Male - etiology; Recurrence - etiology