Medizinische Universität Graz - Research portal
Selected Publication:
Neumeister, P; Jaeger, G; Eibl, M; Sormann, S; Zinke, W; Linkesch, W.
Amifostine in combination with erythropoietin and G-CSF promotes multilineage hematopoiesis in patients with myelodysplastic syndrome.
Leuk Lymphoma. 2001; 40(3-4):345-349
Doi: 10.3109/10428190109057933
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- Leading authors Med Uni Graz
- Neumeister Peter
- Co-authors Med Uni Graz
- Eibl Margit
- Jaeger Gerald
- Linkesch Werner
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- Abstract:
- Ineffective hematopoiesis leading to profound cytopenias represents a major clinical problem in the management of patients with myelodysplastic syndrome (MDS). The aminothiol amifostine has shown to promote multilineage hematopoiesis both in vivo and in vitro in patients with MDS. We have treated 10 patients with 250 mg/m2 amifostine thrice weekly in combination with erythropoietin for 4 consecutive weeks followed by 2 weeks observation. Responding patients received the same 6 week schedule, while nonresponder received G-CSF in addition to erythropoietin and amifostine during the second treatment course. All patients experienced single or multilineage hematologic improvement, but only 2 reached transfusion independency. Moreover, response was durable only in a minority of patients and thus additional studies are warranted to further define the potential interaction of amifostine and growth factors.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Amifostine - administration and dosage
- Antineoplastic Combined Chemotherapy Protocols - administration and dosage
- Blood Cell Count - administration and dosage
- Cell Lineage - administration and dosage
- Erythropoietin - administration and dosage
- Granulocyte Colony-Stimulating Factor - administration and dosage
- Hematopoiesis - drug effects
- Humans - drug effects
- Middle Aged - drug effects
- Myelodysplastic Syndromes - blood
- Treatment Outcome - blood
- Find related publications in this database (Keywords)
- MDS
- amifostine
- growth factor
- therapy
- response