Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Krametter, D; Niederwieser, G; Berghold, A; Birnbaum, G; Strasser-Fuchs, S; Hartung, HP; Archelos, JJ.
Chlamydia pneumoniae in multiple sclerosis: humoral immune responses in serum and cerebrospinal fluid and correlation with disease activity marker.
Mult Scler. 2001; 7(1):13-18
Doi: 10.1191%2F135245801676514804
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- Führende Autor*innen der Med Uni Graz
- Archelos-Garcia Juan-Jose
- Co-Autor*innen der Med Uni Graz
- Berghold Andrea
- Fuchs Siegrid
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- Abstract:
- Humoral immune responses to Chlamydia pneumoniae (C. pneumoniae) were studied in paired sera and cerebrospinal fluid (CSF) of patients with definite multiple sclerosis (MS) and other inflammatory and non-inflammatory neurological diseases. Seropositivity was not significantly different between these groups. However, C. pneumoniae-specific IgG titers were significantly higher in CSF of MS than in controls. Sixteen out of 52 seropositive MS patients (30.8%) showed intrathecal synthesis of C. pneumoniae-specific IgG but only one of 43 seropositive controls (2.3%). In MS, this was strongly associated with intrathecal synthesis of polyclonal IgG in 13/16 patients. However, these elevated C. pneumoniae antibody titers in CSF did not significantly correlate with disease duration, disease course, clinical or MRI disease activity, disability or presence of oligoclonal IgG in MS.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Antibodies, Bacterial - biosynthesis
- Antibodies, Viral - blood
- Antibody Specificity - blood
- Autoimmune Diseases - blood
- Cerebrospinal Fluid Proteins - biosynthesis
- Chlamydia Infections - complications
- Chlamydophila pneumoniae - immunology
- Chronic Disease - immunology
- Female - immunology
- Herpesvirus 4, Human - immunology
- Humans - immunology
- Immunoglobulin G - biosynthesis
- Inflammation - biosynthesis
- Magnetic Resonance Imaging - biosynthesis
- Male - biosynthesis
- Measles virus - immunology
- Middle Aged - immunology
- Multiple Sclerosis - blood
- Mumps virus - immunology
- Nervous System Diseases - blood
- Prevalence - blood
- Seroepidemiologic Studies - blood
- Find related publications in this database (Keywords)
- multiple sclerosis
- chlamydia pneumoniae
- antibody
- serum
- CSF