Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Pfragner, R; Ullmann, R; Behmel, A; Popper, HH.
Comparative genomic hybridization and cytogenetic analysis in a bronchial adenoma: three clones with different chromosomal aberrations.
Int J Oncol. 2001; 18(5):923-928
Doi: 10.3892/ijo.18.5.923
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Pfragner Roswitha
- Popper Helmuth
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- Abstract:
- Classical chromosomal analysis and comparative genomic hybridization (CGH) were performed in a tubular bronchial gland adenoma. Trisomy of chromosomes 2, 11, 18 and 20 and clonal loss of Y were found in cultured cells derived from two different kryotubes; this was also confirmed by CGH from one of these tubes. Cells from two other tubes, investigated by CGH only, showed gains and losses of parts of chromosome 11q in one, and in the second additional gain of the distal portion of 9q and 17q, respectively. CGH analysis of tumor DNA extracted from paraffin-embedded sections showed no chromosomal imbalances. In cell culture growth the advantage of specific clones probably altered the clone distribution. This study highlights the risk of cytogenetic analysis based on cell cultures only.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenoma - genetics
- Bronchial Neoplasms - genetics
- Chromosome Aberrations - genetics
- Chromosome Mapping - methods
- Cytogenetics - methods
- DNA, Neoplasm - analysis
- Humans - analysis
- In Situ Hybridization - methods
- Karyotyping - methods
- Male - methods
- Middle Aged - methods
- Tumor Cells, Cultured - methods
- Find related publications in this database (Keywords)
- bronchial adenoma
- tubular type
- chromosomal aberrations
- clonality
- comparative genomic hybridization