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Bolzer, A; Craig, JM; Cremer, T; Speicher, MR.
A complete set of repeat-depleted, PCR-amplifiable, human chromosome-specific painting probes.
Cytogenet Cell Genet. 1999; 84(3-4):233-240 Doi: 10.1159/000015266
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Leading authors Med Uni Graz: Speicher Michael
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Abstract:: We describe the generation of a complete set of human chromosome-specific painting probes depleted in repetitive sequences. These probes yield highly specific signals when hybridized without the addition of a blocking agent, such as Cot-1 DNA, and without probe preannealing prior to hybridization. Fluorescent intensities and signal-to-background ratios for these probes are comparable to those of untreated probes hybridized with Cot-1 DNA. We demonstrate the suitability of these probes for applications with very complex probe sets, such as multiplex-FISH.
Find related publications in this database (using NLM MeSH Indexing): Binding, Competitive -; Chromosome Painting - methods; Chromosomes, Human - genetics; DNA - genetics; DNA Probes - genetics; Genome, Human - genetics; Humans - genetics; Nucleic Acid Hybridization - genetics; Polymerase Chain Reaction - genetics; Repetitive Sequences, Nucleic Acid - genetics; Reproducibility of Results - genetics; Sensitivity and Specificity - genetics