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Oettl, K; Greilberger, J; Reibnegger, G.
Dihydroneopterin as a scavenger of nitrogen centered radicals
PTERIDINES 2000 11: 90-93. Doi: 10.1515/pteridines.2000.11.3.90
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Leading authors Med Uni Graz: Öttl Karl
Co-authors Med Uni Graz: Greilberger Joachim; Reibnegger Gilbert
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Abstract:: Dihydroneopterin has recently been shown to either promote or decrease formation of free radicals or radical-mediated reactions, depending on the conditions. We report here the scavenging activity of dihydroneopterin on nitrogen centered radicals. Diphenylpicrylhydrazyl (DPPH) and the radical cation of 2,2 ' -azino-di-[3-ethylbenzthiazoline sulphonate] (ABTS) were used. Dihydroneopterin showed scavenging properties against either compound. In the case of DPPH radical scavenging by dihydroneopterin was comparable with trolox. In the ABTS system, dihydroneopterin had an even better capacity of radical scavenging as compared to trolox.