Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Bardelli, A; Cahill, DP; Lederer, G; Speicher, MR; Kinzler, KW; Vogelstein, B; Lengauer, C.
Carcinogen-specific induction of genetic instability.
Proc Natl Acad Sci U S A. 2001; 98(10):5770-5775
Doi: 10.1073/pnas.081082898
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Speicher Michael
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- It has been proposed recently that the type of genetic instability in cancer cells reflects the selection pressures exerted by specific carcinogens. We have tested this hypothesis by treating immortal, genetically stable human cells with representative carcinogens. We found that cells resistant to the bulky-adduct-forming agent 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) exhibited a chromosomal instability (CIN), whereas cells resistant to the methylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) exhibited a microsatellite instability (MIN) associated with mismatch repair defects. Conversely, we found that cells purposely made into CIN cells are resistant to PhIP, whereas MIN cells are resistant to MNNG. These data demonstrate that exposure to specific carcinogens can indeed select for tumor cells with distinct forms of genetic instability and vice versa.
- Find related publications in this database (using NLM MeSH Indexing)
- Blotting, Western -
- Carcinogens - toxicity
- Cell Line - toxicity
- Imidazoles - toxicity
- In Situ Hybridization, Fluorescence - toxicity
- Methylnitronitrosoguanidine - toxicity
- Microsatellite Repeats - drug effects