Medizinische Universität Graz - Research portal
Selected Publication:
Jallepalli, PV; Waizenegger, IC; Bunz, F; Langer, S; Speicher, MR; Peters, JM; Kinzler, KW; Vogelstein, B; Lengauer, C.
Securin is required for chromosomal stability in human cells.
Cell. 2001; 105(4):445-457
Doi: 10.1016/S0092-8674(01)00340-3
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- Co-authors Med Uni Graz
- Speicher Michael
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- Abstract:
- Abnormalities of chromosome number are the most common genetic aberrations in cancer. The mechanisms regulating the fidelity of mitotic chromosome transmission in mammalian cells are therefore of great interest. Here we show that human cells without an hSecurin gene lose chromosomes at a high frequency. This loss was linked to abnormal anaphases during which cells underwent repetitive unsuccessful attempts to segregate their chromosomes. The abnormal mitoses were associated with biochemical defects in the activation of separin, the sister-separating protease, rendering it unable to cleave the cohesin subunit Scc1 efficiently. These results illuminate the function of mammalian securin and show that it is essential for the maintenance of euploidy.
- Find related publications in this database (using NLM MeSH Indexing)
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- Chromosomal Proteins, Non-Histone - genetics
- Chromosome Aberrations - genetics
- Chromosome Disorders - genetics
- Chromosomes, Human - genetics
- Gene Deletion - genetics
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- Humans - genetics
- Mitotic Spindle Apparatus - metabolism
- Molecular Sequence Data - metabolism
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- Nuclear Proteins - physiology
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- Sister Chromatid Exchange - physiology