Medizinische Universität Graz - Research portal
Selected Publication:
Fauth, C; Speicher, MR.
Classifying by colors: FISH-based genome analysis.
Cytogenet Cell Genet. 2001; 93(1-2):1-10
Doi: 10.1159/000056937
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- Leading authors Med Uni Graz
- Speicher Michael
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- Abstract:
- In recent years a fascinating evolution of different multicolor fluorescence in situ hybridization (FISH) technologies could be witnessed. The various approaches to cohybridize multiple DNA probes in different colors opened new avenues for FISH-based automated karyotyping or the simultaneous analysis of multiple defined regions within the genome. These developments had a remarkable impact on microscopy design and the usage of highly sensitive area imagers. In addition, they led to the introduction of new fluorochromes with appropriate filter combinations, refinements of hybridization protocols, novel probe sets, and innovative software for automated chromosome analysis. This paper attempts to summarize the various multicolor approaches and discusses the application of the individual technologies.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Chromosome Painting - methods
- Chromosomes - genetics
- Color - genetics
- DNA Probes - genetics
- Genomics - methods
- Humans - methods
- In Situ Hybridization, Fluorescence - methods
- Karyotyping - methods
- Physical Chromosome Mapping - methods
- Sensitivity and Specificity - methods