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Selected Publication:
Fauth, C; Zhang, H; Harabacz, S; Brown, J; Saracoglu, K; Lederer, G; Rittinger, O; Rost, I; Eils, R; Kearney, L; Speicher, MR.
A new strategy for the detection of subtelomeric rearrangements.
Hum Genet. 2001; 109(6):576-583
Doi: 10.1007/s00439-001-0629-7
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- Co-authors Med Uni Graz
- Speicher Michael
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- Abstract:
- We present a new strategy for the detection of subtelomeric rearrangements. This approach is based on two hybridizations with different probe sets. The first set consists of microdissected subtelomeric probes (each 5-10 megabases in size) labeled combinatorially employing 7 different fluorochromes. With this set, subtelomeric interchromosomal exchanges can be detected in a 24-color experiment. The second set comprises a second generation of subtelomeric PAC-, P1- and BAC-clones. Probes for p- and q-arms are labeled with two different colors. This second set detects small deletions; in addition it provides regional information, so that translocated material identified by the first probe set can be assigned to the p- or q-arm of a chromosome. The test has been evaluated in a blind study on a series of subtle translocations and deletions.
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